M
Mark I-Cheng Chen
Researcher at National University of Singapore
Publications - 163
Citations - 11992
Mark I-Cheng Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Population & Vaccination. The author has an hindex of 38, co-authored 156 publications receiving 8430 citations. Previous affiliations of Mark I-Cheng Chen include University Health System & University of London.
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Journal ArticleDOI
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.
Barnaby Edward Young,Sean Wei Xiang Ong,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,Seow Yen Tan,Jiashen Loh,Oon Tek Ng,Kalisvar Marimuthu,Li Wei Ang,Tze Minn Mak,Sok Kiang Lau,Danielle E. Anderson,Kian Sing Chan,Thean Yen Tan,Thean Yen Tan,Tong Yong Ng,Lin Cui,Zubaidah Said,Lalitha Kurupatham,Mark I-Cheng Chen,Monica Chan,Shawn Vasoo,Lin-Fa Wang,Boon Huan Tan,Raymond T. P. Lin,Vernon J. Lee,Yee Sin Leo,David C. Lye +29 more
TL;DR: Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection and some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent.
Journal ArticleDOI
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
A. Danielle Iuliano,Katherine Roguski,Howard H. Chang,David Muscatello,Rakhee Palekar,Stefano Tempia,Cheryl Cohen,Jon Michael Gran,Jon Michael Gran,Dena L. Schanzer,Benjamin J. Cowling,Peng Wu,Jan Kynčl,Li Wei Ang,Minah Park,Monika Redlberger-Fritz,Hongjie Yu,Laura Espenhain,Anand Krishnan,Gideon O. Emukule,Liselotte van Asten,Susana Silva,Suchunya Aungkulanon,Udo Buchholz,Marc-Alain Widdowson,Joseph S. Bresee,Eduardo Azziz-Baumgartner,Po-Yung Cheng,Fatimah S. Dawood,Ivo M. Foppa,Sonja J. Olsen,Michael Haber,Caprichia Jeffers,C. Raina MacIntyre,Anthony T. Newall,James G. Wood,Michael Kundi,Therese Popow-Kraupp,Makhdum Ahmed,Mahmudur Rahman,Fatima Marinho,C Viviana Sotomayor Proschle,Natalia Vergara Mallegas,Feng Luzhao,Li Sa,Juliana Barbosa-Ramírez,Diana Malo Sanchez,Leandra Abarca Gomez,Xiomara Badilla Vargas,aBetsy Acosta Herrera,María Josefa Llanés,Thea Kølsen Fischer,Tyra Grove Krause,Kåre Mølbak,Jens Nielsen,Ramona Trebbien,Alfredo Bruno,Jenny Ojeda,Hector Ramos,Matthias an der Heiden,Leticia del Carmen Castillo Signor,Carlos Enrique Serrano,Rohit Bhardwaj,Mandeep S. Chadha,Venkatesh Vinayak Narayan,Soewarta Kosen,Michal Bromberg,Aharona Glatman-Freedman,Zalman Kaufman,Yuzo Arima,Kazunori Oishi,Sandra S. Chaves,Bryan O. Nyawanda,Reem Abdullah Al-Jarallah,Pablo A Kuri-Morales,Cuitláhuac Ruiz Matus,Maria Eugenia Jimenez Corona,Alexander Burmaa,Oyungerel Darmaa,Majdouline Obtel,Imad Cherkaoui,Cees C van den Wijngaard,Wim van der Hoek,Michael G Baker,Don Bandaranayake,Ange Bissielo,Sue Huang,Liza Lopez,Claire Newbern,Elmira Flem,Gry M Grøneng,Siri Hauge,Federico G de Cosío,Yadira De Molto,Lourdes Moreno Castillo,María Agueda Cabello,Marta Von Horoch,José L. Medina Osis,Ausenda Machado,Baltazar Nunes,Ana Paula Rodrigues,Emanuel Rodrigues,Cristian Calomfirescu,Emilia Lupulescu,Rodica Popescu,Odette Popovici,Dragan Bogdanovic,Marina Kostic,Konstansa Lazarevic,Zoran Milosevic,Branislav Tiodorovic,Mark I-Cheng Chen,Jeffery Cutter,Vernon J. Lee,Raymond T. P. Lin,Stefan Ma,Adam L. Cohen,Florette K. Treurnicht,Woo Joo Kim,Concha Delgado-Sanz,Salvador de mateo Ontañón,Amparo Larrauri,Inmaculada León,Fernando Vallejo,Rita Born,Christoph Junker,Daniel Koch,Jen-Hsiang Chuang,Wan-Ting Huang,Hung-Wei Kuo,Yi-Chen Tsai,Kanitta Bundhamcharoen,Malinee Chittaganpitch,Helen K. Green,Richard Pebody,Natalia Goñi,Hector Chiparelli,Lynnette Brammer,Desiree Mustaquim +138 more
TL;DR: These global influenza-associated respiratory mortality estimates are higher than previously reported, suggesting that previous estimates might have underestimated disease burden.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
Journal ArticleDOI
A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.
Chee Wah Tan,Wan Ni Chia,Xijian Qin,Pei Liu,Mark I-Cheng Chen,Charles Tiu,Zhiliang Hu,Zhiliang Hu,Vivian Chih Wei Chen,Barnaby Edward Young,Barnaby Edward Young,Wan Rong Sia,Yee-Joo Tan,Yee-Joo Tan,Randy Foo,Yongxiang Yi,David C. Lye,Danielle E. Anderson,Lin-Fa Wang +18 more
TL;DR: A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.
Journal ArticleDOI
Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures.
Rachael Pung,Calvin J Chiew,Barnaby Edward Young,Sarah Chin,Mark I-Cheng Chen,Hannah E. Clapham,Alex R. Cook,Sebastian Maurer-Stroh,Sebastian Maurer-Stroh,Matthias Paul Han Sim Toh,Cuiqin Poh,Mabel Low,Joshua Lum,Valerie T J Koh,Tze M. Mak,Lin Cui,Raymond T. P. Lin,Derrick Heng,Yee Sin Leo,David C. Lye,Vernon J. Lee,Kai Qian Kam,Shirin Kalimuddin,Seow Yen Tan,Jiashen Loh,Koh Cheng Thoon,Shawn Vasoo,Shawn Vasoo,Wei Xin Khong,Nur Afidah Suhaimi,Sherlynn Jh Chan,Emma Zhang,Olivia Seen Huey Oh,Albert Ty,Charlene Tow,Yi Xian Chua,Wei Liang Chaw,Yixiang Ng,Farid Abdul-Rahman,Shafiq Sahib,Zheng Zhao,Cheryl Tang,Constance Low,Ee Hui Goh,Georgina Lim,Yan'an Hou,Imran Roshan,James Tan,Kelly Foo,Khine Nandar,Lalitha Kurupatham,Pei Pei Chan,Pream Raj,Yijun Lin,Zubaidah Said,Anne Lee,Cherie See,Jessey Markose,Joanna Tan,Guanhao Chan,Wanhan See,Xinyi Peh,Vincent Cai,Wen Kai Chen,Zongbin Li,Roy Jiunn Jye Soo,Angela Lp Chow,Wycliffe E. Wei,Aysha Farwin,Li Wei Ang +69 more
TL;DR: SARS-CoV-2 is transmissible in community settings, and local clusters of COVID-19 are expected in countries with high travel volume from China before the lockdown of Wuhan and institution of travel restrictions.