Weidong Li

TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.

TL;DR: A new approach of ultrafiltration coupled with high-performance liquid chromatography and quadrupole-time-of-flight mass spectrometry was established for rapidly detecting lipase binders from different extracts of medicinal plants and identified eleven lipase inhibitors, eight of which were reported for the first time.

TL;DR: This comprehensive review focused on the mechanisms of mitochondrial targeting and a variety of strategies to realize the purpose of mitochondria targeting, including that based on the use of lipophilic cations, and mitochondrial targeting signal peptides (MTS) as well as cell-penetrating peptide (CPPs).

TL;DR: It is concluded that xanthatin displays significant antitumor effects through cell cycle arrest and apoptosis induction in A549 cells, associated with intrinsic apoptosis pathway and disrupted NF-κB signaling.

TL;DR: HA-BSANPs are a promising carrier for articular-related diseases due to elongated articular residence and improved chondrocytic accumulation and compared with BSANPs, haaluronic acid-coated bovine serum albumin nanoparticles exhibited improved uptake by chondROcytes through a receptor-mediated active uptake mechanism.