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Xu-Kun Deng
Researcher at Nanjing University of Chinese Medicine
Publications - 7
Citations - 254
Xu-Kun Deng is an academic researcher from Nanjing University of Chinese Medicine. The author has contributed to research in topics: Brucine & Chemistry. The author has an hindex of 3, co-authored 4 publications receiving 232 citations.
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Journal ArticleDOI
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism
Xu-Kun Deng,Wu Yin,Weidong Li,Fangzhou Yin,Xiaoyu Lu,Xiao-Chun Zhang,Zi-Chun Hua,Baochang Cai +7 more
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.
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The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway.
TL;DR: Ca2+ and Bcl-2 mediated mitochondrial pathway were found to be involved in brucine-induced HepG2 cell apoptosis, and suggested a pivotal role of mitochondrial membrane depolarization in HepG1 cell apoptotic programmed cell death elicited by Brucine.
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The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells.
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against SMMC-7721 cells proliferation, among which brucine proceeds SMMC 7721 cells death via apoptosis, probably through the participation of caspase 3 and cyclooxygenase 2.
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Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade.
TL;DR: Limonin upregulated Smad7 and declined C-terminal phosphorylation and nuclear translocation of Smad2/3 to alleviate mouse CCl4-induced liver fibrosis as mentioned in this paper .
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Facile synthesis of novel poly(1H-benzoindole)/WO3 nanocomposites with enhanced energy storage capability and its application in high-performance supercapacitor
TL;DR: In this paper , an asymmetric supercapacitor based on poly(1H-benzindole)/tungsten trioxide (PBIn/WO3) nanocomposites is successfully prepared by simple hydrothermal synthesis and electrochemical polymerization.