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Wen Chien Huang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 4
Citations - 1575
Wen Chien Huang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Brain metastasis & Breast cancer. The author has an hindex of 4, co-authored 4 publications receiving 1363 citations.
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Journal ArticleDOI
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Lin Zhang,Siyuan Zhang,Siyuan Zhang,Jun Yao,Frank J. Lowery,Qingling Zhang,Wen Chien Huang,Ping Li,Min Li,Xiao Wang,Chenyu Zhang,Hai Wang,Kenneth Ellis,Mujeeburahiman Cheerathodi,Joseph H. McCarty,Diane Palmieri,Jodi M. Saunus,Sunil R. Lakhani,Suyun Huang,Aysegul A. Sahin,Kenneth Aldape,Patricia S. Steeg,Dihua Yu +22 more
TL;DR: A remarkable plasticity of PTEN expression in metastatic tumour cells in response to different organ microenvironments is demonstrated, underpinning an essential role of co-evolution between the metastatic cells and their microenvironment during the adaptive metastatic outgrowth.
Journal ArticleDOI
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
Siyuan Zhang,Wen Chien Huang,Ping Li,Hua Guo,Say Bee Poh,Samuel W. Brady,Samuel W. Brady,Yan Xiong,Ling Ming Tseng,Shau Hsuan Li,Zhaoxi Ding,Aysegul A. Sahin,Francisco J. Esteva,Francisco J. Esteva,Gabriel N. Hortobagyi,Dihua Yu +15 more
TL;DR: It is found that SRC is activated in both acquired and de novo trastuzumab-resistant cells and a novel mechanism of SRC regulation involving dephosphorylation by PTEN is uncovered, suggesting the potential clinical application of this strategy to overcome trastzumab resistance.
Journal ArticleDOI
Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases
Siyuan Zhang,Wen Chien Huang,Lin Zhang,Chenyu Zhang,Frank J. Lowery,Zhaoxi Ding,Hua Guo,Hai Wang,Suyun Huang,Aysegul A. Sahin,Kenneth Aldape,Patricia S. Steeg,Dihua Yu +12 more
TL;DR: A critical role for Src activation in promoting brain metastasis in a preclinical model of breast cancer is revealed and how Src-targeting combinatorial regimens can treat HER2(+) brain metastases in this model is shown.
Journal ArticleDOI
Mitotic Deregulation by Survivin in ErbB2-Overexpressing Breast Cancer Cells Contributes to Taxol Resistance
Jing Lu,Ming Tan,Wen Chien Huang,Ping Li,Hua Guo,Ling Ming Tseng,Xiao Hua Su,Wen Tao Yang,Warapen Treekitkarnmongkol,Michael Andreeff,Fraser Symmans,Dihua Yu +11 more
TL;DR: It is found that ErbB2-overexpressing cells expressed higher levels of survivin in multiple breast cancer cell lines and patient samples, which correlated with the increased resistance to Taxol-induced apoptosis and combination treatment of Taxol with PI3K/Akt and Src inhibitor led to increased apoptosis.