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Aysegul A. Sahin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 345
Citations - 33219
Aysegul A. Sahin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 93, co-authored 322 publications receiving 30038 citations. Previous affiliations of Aysegul A. Sahin include Baylor College of Medicine & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
Yoichi Nagata,Keng-Hsueh Lan,Xiaoyan Zhou,Ming Tan,Francisco J. Esteva,Aysegul A. Sahin,Kristine S. Klos,Ping Li,Brett P. Monia,Nina T. Nguyen,Gabriel N. Hortobagyi,Mien Chie Hung,Dihua Yu +12 more
TL;DR: In this paper, PTEN activation contributes to trastuzumab's antitumor activity and PI3K inhibitors rescued PTEN loss-induced trastusumab resistance.
Journal ArticleDOI
Tumour amplified kinase STK15 / BTAK induces centrosome amplification, aneuploidy and transformation
Hong Yi Zhou,Jian Kuang,Ling Zhong,Wen Lin Kuo,Joe W. Gray,Aysegul A. Sahin,Bill R. Brinkley,Subrata Sen +7 more
TL;DR: It is reported that STK15 (also known as BTAK and aurora2), encoding a centrosome-associated kinase, is amplified and overexpressed in multiple human tumour cell types, and is involved in the induction of centrosomes duplication-distribution abnormalities and aneuploidy in mammalian cells.
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Significantly Higher Pathologic Complete Remission Rate After Neoadjuvant Therapy With Trastuzumab, Paclitaxel, and Epirubicin Chemotherapy: Results of a Randomized Trial in Human Epidermal Growth Factor Receptor 2–Positive Operable Breast Cancer
Aman U. Buzdar,Nuhad K. Ibrahim,Deborah Francis,Daniel J. Booser,Eva Thomas,Richard L. Theriault,Lajos Pusztai,Marjorie C. Green,Banu Arun,Sharon H. Giordano,Massimo Cristofanilli,Debra Frye,Terry L. Smith,Kelly K. Hunt,Sonja E. Singletary,Aysegul A. Sahin,Michael S. Ewer,Thomas A. Buchholz,Donald A. Berry,Gabriel N. Hortobagyi +19 more
TL;DR: Adding trastuzumab to chemotherapy, as used in this trial, significantly increased pathologic complete response (pCR) rate without clinical congestive heart failure, according to the small sample size.
Journal ArticleDOI
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Katherine Stemke-Hale,Ana M. Gonzalez-Angulo,Ana Lluch,Richard M. Neve,Wen Lin Kuo,Michael Davies,Mark S. Carey,Zhi Hu,Yinghui Guan,Aysegul A. Sahin,W. Fraser Symmans,Lajos Pusztai,Laura K. Nolden,Hugo M. Horlings,Katrien Berns,Mien Chie Hung,Marc J. van de Vijver,Vicente Valero,Joe W. Gray,René Bernards,Gordon B. Mills,Bryan T. Hennessy +21 more
TL;DR: PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes and the specific aberration present may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.
Journal ArticleDOI
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Lin Zhang,Siyuan Zhang,Siyuan Zhang,Jun Yao,Frank J. Lowery,Qingling Zhang,Wen Chien Huang,Ping Li,Min Li,Xiao Wang,Chenyu Zhang,Hai Wang,Kenneth Ellis,Mujeeburahiman Cheerathodi,Joseph H. McCarty,Diane Palmieri,Jodi M. Saunus,Sunil R. Lakhani,Suyun Huang,Aysegul A. Sahin,Kenneth Aldape,Patricia S. Steeg,Dihua Yu +22 more
TL;DR: A remarkable plasticity of PTEN expression in metastatic tumour cells in response to different organ microenvironments is demonstrated, underpinning an essential role of co-evolution between the metastatic cells and their microenvironment during the adaptive metastatic outgrowth.