W
Wen-Ching Wang
Researcher at National Tsing Hua University
Publications - 56
Citations - 1667
Wen-Ching Wang is an academic researcher from National Tsing Hua University. The author has contributed to research in topics: Helicobacter pylori & Prostate cancer. The author has an hindex of 22, co-authored 53 publications receiving 1389 citations. Previous affiliations of Wen-Ching Wang include National Chung Hsing University.
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Journal ArticleDOI
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism
Hung Jung Wang,Ya-Ju Hsieh,Wen-Chi Cheng,Chun Pu Lin,Yu Shan Lin,So Fang Yang,Chung Ching Chen,Yoshihiro Izumiya,Jau-Song Yu,Hsing Jien Kung,Hsing Jien Kung,Wen-Ching Wang +11 more
TL;DR: In this article, a Jumonji C domain-containing dioxygenase, called JMJD5, is shown to be upregulated by hypoxia and is crucial for hypoxiosis-induced cell proliferation.
Journal ArticleDOI
An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example
Chia Yang Cheng,Chia-Han Chu,Hung Wei Hsu,Fang-Rong Hsu,Chung Yi Tang,Chung Yi Tang,Wen-Ching Wang,Hsing Jien Kung,Hsing Jien Kung,Hsing Jien Kung,Pei Ching Chang +10 more
TL;DR: An improved approach is described that enhances ChIP-seq data analysis and allows the identification of multiple SUMOylated TF binding sites simultaneously, which can then be utilized for other functional PTM binding site prediction in future.
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KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
Chia-Han Chu,Ling Yu Wang,Kai Cheng Hsu,Chung Chin Chen,Hsing Hung Cheng,Szu Min Wang,Chien Ming Wu,Tsan Jan Chen,Ling Ting Li,Ruiwu Liu,Chiu-Lien Hung,Jing Moon Yang,Hsing Jien Kung,Hsing Jien Kung,Wen-Ching Wang +14 more
TL;DR: The crystal structure of the KDM4B·pyridine 2,4-dicarboxylic acid·H3K9me3 ternary complex is reported, revealing the core active-site region and a selective K9/K36 site and a new inhibitor scaffold is identified by virtual screening.
Journal ArticleDOI
Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes
TL;DR: It is suggested that s1a/m1T strains are associated with increased cytotoxic activity and higher ulcer prevalence than are s1 a/m2 strains.
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KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC
Hung Jung Wang,Mamata R. Pochampalli,Ling Yu Wang,June X. Zou,Pei Shan Li,Sheng Chieh Hsu,Sheng Chieh Hsu,Bi Juan Wang,Shih Han Huang,Ping Yang,Ping Yang,Joy C. Yang,Cheng Ying Chu,Chia Ling Hsieh,Shian Ying Sung,Chien-Feng Li,Clifford G. Tepper,David K. Ann,David K. Ann,Allen C. Gao,Allen C. Gao,Christopher P. Evans,Yoshihiro Izumiya,Chi Pin Chuu,Wen-Ching Wang,Hongwu Chen,Hsing Jien Kung +26 more
TL;DR: KDM8 thus presents itself as an ideal therapeutic target for metabolic adaptation and castration-resistance of prostate cancer cells and is validated as a regulator for both androgen-responsive and metabolic genes.