Wen Fan

TL;DR: Proteome-wide association studies of brain samples from older adults revealed effects of cerebral atherosclerosis and Alzheimer’s disease, and a subset of proteins and protein co-expression modules were associated with both, suggesting shared mechanisms.

TL;DR: Four brain microRNAs are identified and a molecular connection between late-life depression and dementia through miR-484 is found, found in a brain protein co-expression module involving synaptic transmission and regulation of synaptic plasticity.

TL;DR: In this article, the authors generated an online brain pQTL resource for 7,376 proteins through the analysis of genetic and proteomic data derived from post-mortem samples of the dorsolateral prefrontal cortex of 330 older adults.

TL;DR: The results suggest that the genetic control of mRNA and protein abundance may be substantially distinct and suggests inference concerning protein abundance made from mRNA in human brain should be treated with caution.

TL;DR: This is the first study to identify brain microRNAs associated with late- life depressive symptoms assessed longitudinally and find a link between late-life depressive symptoms and dementia throughmiR-484 and miR-197.