Wen-Hsuan W. Lin

TL;DR: In this paper, the authors show distinct antibody responses in children and adults after SARS-CoV-2 infection, indicating a distinct infection course and immune response in children independent of whether they develop multisystem inflammatory syndrome (MIS-C).

TL;DR: In a randomized, double-blind, controlled trial among adults hospitalized with severe and critical COVID-19 at 5 sites in New York City (USA) and Rio de Janeiro (Brazil), patients were randomized 2:1 to receive either convalescent plasma or normal control plasma as discussed by the authors.

TL;DR: Identification of the immune mechanisms required for the clearance of MeV RNA from multiple sites will enlighten the understanding of the development of disease owing to persistent infection.

TL;DR: It is found that viral RNA persisted in the blood, respiratory tract, or lymph nodes four to five times longer than the infectious virus and that the clearance of MeV RNA from blood happened in three phases: rapid decline coincident with clearance of infectious virus, a rebound phase with increases up to 10-fold, and a phase of slow decrease to undetectable levels.

TL;DR: It is shown that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this requires cell division, which may promote clonal amplification and memory cell formation in acute infections.