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Wen-Juan Xu
Researcher at Bengbu Medical College
Publications - 13
Citations - 291
Wen-Juan Xu is an academic researcher from Bengbu Medical College. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 7, co-authored 11 publications receiving 235 citations.
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Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
Journal ArticleDOI
Upregulation of hypoxia inducible factor 1alpha mRNA is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinoma.
TL;DR: HIF-1alpha may induce the angiogenesis in gastric carcinoma by upregulating the transcription of VEGF gene, and take part in tumor invasion and metastasis and can be used as prognostic markers of gastric cancer in clinical practice.
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Prognostic Value and Clinical Pathology of MACC-1 and c-MET Expression in Gastric Carcinoma
TL;DR: It is confirmed that MACC-1 and c-MET expression is strongly related to gastric cancer stage and degree of malignancy, and is inversely correlated to patient prognosis.
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HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs.
Xujun He,Zhengchuang Liu,Ying-Jie Xia,Ji Xu,Guocai Lv,Lu Wang,Tonghui Ma,Liping Jiang,Yiping Mou,Xiao-Ting Jiang,Jie Ma,Zhong-kuo Zhao,Haibin Ni,Wen-Juan Xu,Guo-Qing Ru,Dong-Sheng Huang,Hou-Quan Tao +16 more
TL;DR: The results showed that increased expression of HOXB7 might play an important role in promoting GC proliferation, migration and invasion by inducing both AKT and MAPK pathways, thus resulting in progression of, and poor prognosis in GC patients.
Journal ArticleDOI
CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma
Guo-Qing Ru,Yong Han,Wei Wang,Yuan Chen,Hui-Ju Wang,Wen-Juan Xu,Jie Ma,Mei-Hua Ye,Xi Chen,Xiang-Lei He,Balázs Győrffy,Balázs Győrffy,Zhong-Sheng Zhao,Dong-Sheng Huang +13 more
TL;DR: Data mining results show that CEACAM6 is overexpressed in gastric cancer and is correlated with lymph node metastasis, and data mining discovered that Tamoxifen etc. could be therapeutic alternatives for gastric patients with CEACam6 overexpression.