Showing papers in "European Journal of Cancer in 2015"

TL;DR: Increasing trends in incidence of the most common cancers, except stomach cancer, are bad news to public health but can largely be explained by well-known changes in society in the past decades.

TL;DR: C- or P-based therapy did not increase the benefit of standard therapy or the BSC in RAS-wt/BRAF-mut CRC patients, and findings support BRAF mutation assessment before initiation of treatment with anti-EGFR monoclonal antibodies.

TL;DR: The EDF-EADO-EORTC consensus group recommends a standardised minimal margin of 5 mm even for low-risk tumours and a lymph node ultrasound is highly recommended, particularly in tumours with high-risk characteristics.

TL;DR: This is the first randomised study using the IMRT technique for APBI delivery and no significant difference in terms of IBTR and overall survival was observed between the two arms.

TL;DR: A collaborative group of multidisciplinary experts form the European Dermatology Forum (EDF), The European Association of Dermato-Oncology (EADO) and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on MCC diagnosis and management.

TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.

TL;DR: This study shows survival progresses during the study period, however, slightly more than half of patients were diagnosed with regional or metastatic disease at diagnosis, which is crucial to reduce the European gap to further improve H&N cancers outcome.

TL;DR: The LORD study aims to evaluate the safety of active surveillance in women with low-risk DCIS to explore interest in and feasibility of this randomised, international multicentre, open-label, phase III non-inferiority trial.

TL;DR: The background and development of 'The low risk' DCIS trial (LORIS), a phase III trial of surgery versus active monitoring, will determine if it is appropriate to manage women with screen detected or asymptomatic, low grade and intermediate grade DCIS with low grade features, by active monitoring rather than by surgical treatment.

TL;DR: In refractory MCC, tumour location within the colon is not prognostic, but is strongly predictive of PFS benefit from cetuximab therapy, and additional research is needed to understand the molecular differences between RC and LC and their interaction with EGFR inhibition.

TL;DR: Data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer.

TL;DR: This is the first study to systematically characterise the clinical implications of particular acquired BRAFi-resistance mechanisms in patients with BRAF-mutant melanoma and the largest study to compile the landscape of resistance.

TL;DR: Substantial LVSI was the strongest independent prognostic factor for pelvic regional recurrence, distant metastasis and overall survival and should be considered for stage I EC with substantial LVSI.

TL;DR: IMRT provided an improved LRFS, LRRFS and PFS in both the early and advanced T classifications and overall stage for non-disseminated NPC compared with 2D-CRT, however, no significant advantage was observed in NRFS, DMFS or OS when IMRT was used.

TL;DR: An increased participation was observed in the self-Sampling arm compared to the control arm, if self-sampling kits were sent directly to women at their home address, however, the size of the effect varied substantially among studies.

TL;DR: Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care.

TL;DR: Recurrent exposure to certain antibiotics may be associated with cancer risk in specific organ sites in humans using a large population-based electronic medical record database.

TL;DR: Patients with RAS-mutant mCRC, as defined by mutations in KRAS and NRAS exons 2-4, derive no benefit and may be harmed by the addition of cetuximab to FOLFOX4, reports outcomes in subgroups defined by extended RAS testing.

TL;DR: A review aims to describe these putative miRNAs in altering the WNT/β-catenin signalling in EMT, and whether targeting them is a useful therapeutic option for human invasive tumours.

TL;DR: Besides conventional immunohistochemistry, RNA-seq seems suitable for detection of PD-L1/PD-L2 expression and might prove to be more sensitive and evaluation of the composition of the tumour microenvironment should be included in clinical trials.

TL;DR: Although the overall trial did not meet its survival endpoint, improved survival for belagenpumatucel-L is suggested in patients who were randomised within 12weeks of completion of chemotherapy and in those who had received prior radiation.

TL;DR: A consensus treatment algorithm based on professionals' AND patients' expertise is proposed based on a round table meeting bringing together sarcoma experts from the European Organisation for Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group (STBSG) with patient advocates from SarcomA Patients EuroNet (SPAEN).

TL;DR: The addition of HPVs 31/33/45/52/58 to HPV types included in current vaccines (HPV16/18) could prevent almost 90% of HPV positive female anogenital lesions worldwide and take into account that most HPV-related cancers are ICC ones, the 9-valent HPV vaccine could potentially avoid almost 88% of all female anogenic cancers.

TL;DR: Evidence from this study indicates that consumption of total fruit and white vegetables, but not total vegetables, was inversely associated with gastric cancer risk, and concordant positive associations between high-salt foods and gastriccancer risk were found.

TL;DR: There is an urgent need for nation- and state-wide awareness programmes, engaging multiple stakeholders of society and the health system, to help improve cancer literacy in India.

TL;DR: This study, albeit negative, contains hypothesis generating signals supporting evaluation of correlative, efficacy-predicting tumour parameters for nimotuzumab in the treatment of glioblastoma.

TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.

TL;DR: The concepts of ETS and DpR offer potential as clinical end-points to aid the clinical decision making process and thus further optimise mCRC patient management in the era of tailored therapy approaches.

TL;DR: Pleomorphic carcinoma of the lung is a rare type of poorly differentiated non-small cell lung carcinoma that belongs to sarcomatoid carcinoma (SC) that exhibits aggressive behaviour and resistance to chemotherapy and radiotherapy and targeting the PD-1/PD-L1 pathway may represent a potential therapeutic candidate for this aggressive tumour.

TL;DR: The overall outcome for patients with GBM remains poor, however, aggressive treatment at every age group is associated with extended survival similar to that described in clinical trials.