Dong-Sheng Huang

TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.

TL;DR: A new avenue for TNBC treatment is opened by targeting the EZH2-H3K27me3-TET1 pathway that can modulate the epigenetic landscape and provide evidence regarding how to exploit it as a novel therapeutic target via its pivotal role in senescence and apoptosis control.

TL;DR: The results showed that increased expression of HOXB7 might play an important role in promoting GC proliferation, migration and invasion by inducing both AKT and MAPK pathways, thus resulting in progression of, and poor prognosis in GC patients.

TL;DR: This study discovered two germline ATM mutations in a Chinese family with a history of gastric cancer by screening 83 cancer susceptibility genes and found deleterious germline mutations of ATM in 2.7% of 335 Gastric cancer patients of different ethnic origins.

TL;DR: Data mining results show that CEACAM6 is overexpressed in gastric cancer and is correlated with lymph node metastasis, and data mining discovered that Tamoxifen etc. could be therapeutic alternatives for gastric patients with CEACam6 overexpression.