Z
Zhaohui Wang
Researcher at Duke University
Publications - 13
Citations - 1455
Zhaohui Wang is an academic researcher from Duke University. The author has contributed to research in topics: Glioma & Mutation. The author has an hindex of 10, co-authored 13 publications receiving 1180 citations. Previous affiliations of Zhaohui Wang include Beijing Institute of Genomics.
Papers
More filters
Journal ArticleDOI
Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Hai Yan,Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,G.L. Gallia,B.C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,R.H. Hruban,G.I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.A. Rasheed,Gregory J. Riggins,T.A. Rosenquist,M. Schiffman,IeM Shih,Dan Theodorescu,M.S. Torbenson,Victor E. Velculescu,Tian Li Wang,N. Wentzensen,Laura D. Wood,Ming Zhang,Patrick Healy,Rui Yang,Bill H. Diplas,Zhaohui Wang,Paula K. Greer,Huishan Zhu,Catherine Y. Wang,Austin B. Carpenter,James E. Herndon,Roger E. McLendon,Kenneth W. Kinzler,Bert Vogelstein,N. Papadopoulos,Darell D. Bigner +45 more
TL;DR: TERT and ATRX mutations suggest that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Mutations in IDH1 , IDH2 , and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas
Patrick J. Killela,Christopher J. Pirozzi,Patrick Healy,Zachary J. Reitman,Eric S. Lipp,Ahmed Rasheed,Rui Yang,Bill H. Diplas,Zhaohui Wang,Paula K. Greer,Huishan Zhu,Catherine Y. Wang,Austin B. Carpenter,Henry S. Friedman,Allan H. Friedman,Stephen T. Keir,Jie He,Yiping He,Roger E. McLendon,James E. Herndon,Hai Yan,Darell D. Bigner +21 more
TL;DR: It is hypothesized and show that genetic signatures capable of distinguishing among several types of gliomas could be established providing clinically relevant information that can serve as an adjunct to histopathological diagnosis.
Journal ArticleDOI
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Liwei Zhang,Lee H. Chen,Hong Wan,Rui Yang,Zhaohui Wang,Jie Feng,Shao-Hua Yang,Siân Jones,Wang Sizhen,Weixin Zhou,Huishan Zhu,Patrick J. Killela,Junting Zhang,Zhen Wu,Guilin Li,Shuyu Hao,Yu Wang,Joseph B Webb,Henry S. Friedman,Allan H. Friedman,Roger E. McLendon,Yiping He,Zachary J. Reitman,Darell D. Bigner,Hai Yan +24 more
TL;DR: The discovery of tumor-specific mutations in PPM1D, encoding wild-type p53–induced protein phosphatase 1D (WIP1), in 37.5% of the BSGs that harbored hallmark H3F3A mutations encoding p.Lys27Met substitutions is defined as a frequent target of somatic mutation and as a potential therapeutic target in brainstem gliomas.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
Journal ArticleDOI
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
Bill H. Diplas,Xujun He,Jacqueline A. Brosnan-Cashman,Heng Liu,Lee H. Chen,Zhaohui Wang,Casey J. Moure,Patrick J. Killela,Daniel B. Loriaux,Eric S. Lipp,Paula K. Greer,Rui Yang,Anthony J. Rizzo,Fausto J. Rodriguez,Allan H. Friedman,Henry S. Friedman,Wang Sizhen,Yiping He,Roger E. McLendon,Darell D. Bigner,Yuchen Jiao,Matthew S. Waitkus,Alan K. Meeker,Hai Yan +23 more
TL;DR: The authors present a genetic landscape of TERTpWT-IDHWT glioblastoma, identifying a telomerase- positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.