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Wendy Westbroek
Researcher at National Institutes of Health
Publications - 70
Citations - 3856
Wendy Westbroek is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Glucocerebrosidase & Lysosome. The author has an hindex of 33, co-authored 69 publications receiving 3477 citations. Previous affiliations of Wendy Westbroek include Ghent University Hospital & Children's Hospitals and Clinics of Minnesota.
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Journal ArticleDOI
Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics.
TL;DR: This review discusses the main components of LRO biogenesis, and summarizes the function, composition, and resident cell types of the major LROs.
Journal ArticleDOI
Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis
An Hendrix,Dawn M. Maynard,Patrick Pauwels,Geert Braems,Hannelore Denys,Rudy Van den Broecke,Jo Lambert,Simon Van Belle,Veronique Cocquyt,Christian Gespach,Marc Bracke,Miguel C. Seabra,William A. Gahl,Olivier De Wever,Wendy Westbroek +14 more
TL;DR: Rab27B regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.
Journal ArticleDOI
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
Elma Aflaki,Daniel K. Borger,Nima Moaven,Barbara K. Stubblefield,Steven A. Rogers,Samarjit Patnaik,Frank J. Schoenen,Wendy Westbroek,Wei Zheng,Patricia Sullivan,Hideji Fujiwara,Rohini Sidhu,Zayd M. Khaliq,Grisel Lopez,David S. Goldstein,Daniel S. Ory,Juan J. Marugan,Ellen Sidransky +17 more
TL;DR: Dopaminergic neurons were generated from iPSC lines derived from patients with Gaucher disease with and without parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.
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α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases
Thai Leong Yap,James M. Gruschus,Arash Velayati,Wendy Westbroek,Ehud Goldin,Nima Moaven,Ellen Sidransky,Jennifer C. Lee +7 more
TL;DR: It is suggested that the α-syn-GCase association is favored in the lysosome, and that this noncovalent interaction provides the groundwork to explore molecular mechanisms linking PD with mutant GBA alleles.
Journal ArticleDOI
Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding
Olivier De Wever,Wendy Westbroek,An Verloes,Nele Bloemen,Marc Bracke,Christian Gespach,Erik Bruyneel,Marc Mareel +7 more
TL;DR: It is shown that cancer-cell-derived transforming growth factor-β (TGF-β) is required and sufficient for invasion of myofibroblasts, and a new mechanism in which cancer cells contribute to the coordination of invasion of stromal my ofibro Blasts is identified.