G
Grisel Lopez
Researcher at National Institutes of Health
Publications - 85
Citations - 5781
Grisel Lopez is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Parkinsonism & Glucocerebrosidase. The author has an hindex of 28, co-authored 73 publications receiving 4933 citations. Previous affiliations of Grisel Lopez include George Washington University.
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Journal ArticleDOI
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simón-Sánchez,Claudia Schulte,Jose Bras,Jose Bras,Manu Sharma,J. Raphael Gibbs,J. Raphael Gibbs,Daniela Berg,Coro Paisán-Ruiz,Peter Lichtner,Sonja W. Scholz,Sonja W. Scholz,Dena G. Hernandez,Dena G. Hernandez,Rejko Krüger,Monica Federoff,Christine Klein,Alison Goate,Joel S. Perlmutter,Michael Bonin,Mike A. Nalls,Thomas Illig,Christian Gieger,Henry Houlden,Michael Steffens,Michael S. Okun,Brad A. Racette,Mark R. Cookson,Kelly D. Foote,Hubert H. Fernandez,Bryan J. Traynor,Stefan Schreiber,Sampath Arepalli,Ryan R. Zonozi,Katrina Gwinn,Marcel P. van der Brug,Marcel P. van der Brug,Grisel Lopez,Stephen J. Chanock,Arthur Schatzkin,Yikyung Park,Albert R. Hollenbeck,Jianjun Gao,Xuemei Huang,Nicholas W. Wood,Delia Lorenz,Günther Deuschl,Honglei Chen,Olaf Riess,John Hardy,Andrew B. Singleton,Thomas Gasser +51 more
TL;DR: It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided.
Journal ArticleDOI
The link between the GBA gene and parkinsonism
Ellen Sidransky,Grisel Lopez +1 more
TL;DR: Identification of the pathological mechanisms underlying GBA-associated parkinsonism will improve the understanding of the genetics, pathophysiology, and treatment for both rare and common neurological diseases.
Journal ArticleDOI
A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
Mike A. Nalls,Raquel Duran,Grisel Lopez,Marzena Kurzawa-Akanbi,Ian G. McKeith,Patrick F. Chinnery,Christopher Morris,Jessie Theuns,Jessie Theuns,David Crosiers,David Crosiers,Patrick Cras,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,David M. A. Mann,Julie S. Snowden,Stuart Pickering-Brown,Nicola Halliwell,Yvonne S Davidson,Linda Gibbons,Jenny Harris,Una-Marie Sheerin,Jose Bras,John Hardy,Lorraine N. Clark,Karen Marder,Lawrence S. Honig,Daniela Berg,Walter Maetzler,Kathrin Brockmann,Thomas Gasser,Fabiana Novellino,Aldo Quattrone,Grazia Annesi,Elvira Valeria De Marco,Ekaterina Rogaeva,Mario Masellis,Mario Masellis,Sandra E. Black,Sandra E. Black,Juan M. Bilbao,Tatiana Foroud,Bernardino Ghetti,William C. Nichols,Nathan Pankratz,Glenda M. Halliday,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Stephan Klebe,Alexandra Durr,Charles Duyckaerts,Charles Duyckaerts,Charles Duyckaerts,Alexis Brice,Benoit I. Giasson,John Q. Trojanowski,Howard I. Hurtig,Nahid Tayebi,Claudia Landazabal,Claudia Landazabal,Melanie A. Knight,Margaux F. Keller,Margaux F. Keller,Andrew B. Singleton,Tyra G. Wolfsberg,Ellen Sidransky +68 more
TL;DR: In this paper, the authors found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88).
Journal ArticleDOI
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandra Beilina,Iakov N. Rudenko,Alice Kaganovich,Laura Civiero,H. Chau,Suneil K. Kalia,Lorraine V. Kalia,Evy Lobbestael,Ruth Chia,Kelechi Ndukwe,J. Ding,Mike A. Nalls,Maciej B. Olszewski,David N. Hauser,Ravindran Kumaran,Andres M. Lozano,Veerle Baekelandt,Lois E. Greene,Jean-Marc Taymans,Elisa Greggio,M. R. Cookson,Vincent Plagnol,Maria Martinez,Dena G. Hernandez,Dena G. Hernandez,Manu Sharma,UM Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,S. Sveinbjornsdottir,S. Sveinbjornsdottir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Jose Bras,Kathrin Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Sean Chong,Carl E Clarke,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,Omar Gustafsson,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,H. Z. Munchen,Palmi V. Jonsson,Jean-Charles Lambert,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,Olaf Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,Chris C. A. Spencer,Hreinn Stefansson,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Nigel Williams,Caroline H. Williams-Gray,Sophie Winder-Rhodes,Kari Stefansson,John Hardy,Peter Heutink,Alexis Brice,T. Gasser,T. Gasser,Andrew B. Singleton,Nicholas W. Wood,Patrick F. Chinnery,Luigi Ferrucci,Robert L. Johnson,Dan L. Longo,Elisa Majounie,Richard O'Brien,Juan C. Troncoso,M. Van Der Brug,H. R. Zielke,H. R. Zielke,Alan B. Zonderman +168 more
TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.
Journal ArticleDOI
Transcranial Direct Current Stimulation for the Treatment of Parkinson’s Disease
David H. Benninger,Mikhail Lomarev,Grisel Lopez,Eric M. Wassermann,Xiaobai Li,Elaine Considine,Mark Hallett +6 more
TL;DR: In this paper, the authors investigated the efficacy of transcranial direct current stimulation (tDCS) in the treatment of Parkinson9s disease (PD) and found that tDCS improved gait by some measures for a short time and improved bradykinesia in both the on and off states for longer than 3 months.