W
Wengang Chai
Researcher at Imperial College London
Publications - 146
Citations - 9152
Wengang Chai is an academic researcher from Imperial College London. The author has contributed to research in topics: Oligosaccharide & Glycan. The author has an hindex of 51, co-authored 141 publications receiving 8524 citations. Previous affiliations of Wengang Chai include Ocean University of China & A. N. Nesmeyanov Institute of Organoelement Compounds.
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Journal ArticleDOI
Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions
TL;DR: In this article, the authors describe microarrays of oligosaccharides as neoglycolipids and their robust display on nitrocellulose, and show that carbohydrate-recognizing proteins single out their ligands not only in arrays of homogeneous oligosACcharides but also in array of heterogeneous oligo-charides.
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GM1 structure determines SV40-induced membrane invagination and infection
Helge Ewers,Winfried Römer,Winfried Römer,Alicia E. Smith,Kirsten Bacia,Kirsten Bacia,Serge Dmitrieff,Wengang Chai,Roberta Mancini,Jürgen Kartenbeck,Jürgen Kartenbeck,Valérie Chambon,Valérie Chambon,Ludwig Berland,Ludwig Berland,Ariella Oppenheim,Günter Schwarzmann,Ten Feizi,Petra Schwille,Pierre Sens,Ari Helenius,Ludger Johannes,Ludger Johannes +22 more
TL;DR: This analysis indicates that SV40, other polyoma viruses and some bacterial toxins use glycosphingolipids and a common pentameric protein scaffold to induce plasma membrane curvature, thus directly promoting their endocytic uptake into cells.
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Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria.
James G. Beeson,Stephen J. Rogerson,Stephen J. Rogerson,Brian M. Cooke,John C. Reeder,Wengang Chai,Alexander M. Lawson,Malcolm E. Molyneux,Malcolm E. Molyneux,Graham Brown,Graham Brown +10 more
TL;DR: It is reported here that most P. falciparum isolates from infected placentae can bind to hyaluronic acid, a newly discovered receptor for parasite adhesion that is present on the placental lining, changing the present understanding of the mechanisms of placental infection.
Journal ArticleDOI
Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray
Robert A. Childs,Angelina S. Palma,Steve A. Wharton,Tatyana Matrosovich,Yan Liu,Wengang Chai,María Asunción Campanero-Rhodes,María Asunción Campanero-Rhodes,Yibing Zhang,Markus Eickmann,Makoto Kiso,Alan Hay,Mikhail Matrosovich,Ten Feizi +13 more
TL;DR: Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray is determined by carbohydrates microarray.
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Ligands for the β-glucan receptor, dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides
Angelina S. Palma,Ten Feizi,Yibing Zhang,Mark S. Stoll,Alexander M. Lawson,Esther Díaz-Rodríguez,María Asunción Campanero-Rhodes,Júlia Costa,Siamon Gordon,Gordon D. Brown,Wengang Chai +10 more
TL;DR: In this article, a C-type lectin-like receptor on leukocytes that mediates phagocytosis and inflammatory mediator production in innate immunity to fungal pathogens was identified.