W
Wenhui He
Researcher at Scripps Research Institute
Publications - 25
Citations - 2823
Wenhui He is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Hepatitis B virus & Hepatitis D virus. The author has an hindex of 14, co-authored 23 publications receiving 2274 citations. Previous affiliations of Wenhui He include Peking University & Peking Union Medical College.
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Journal ArticleDOI
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Huan Yan,Guocai Zhong,Guangwei Xu,Wenhui He,Zhiyi Jing,Zhenchao Gao,Yi Huang,Yonghe Qi,Bo Peng,Haimin Wang,Liran Fu,Mei Song,Pan Chen,Wenqing Gao,Bijie Ren,Yinyan Sun,Tao Cai,Xiaofeng Feng,Jianhua Sui,Wenhui Li +19 more
TL;DR: It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
Journal ArticleDOI
Viral entry of Hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide
TL;DR: It is demonstrated that molecular determinants critical for HBV and HDV entry overlap with that for bile salts uptake by NTCP, indicating that viral infection may interfere with the normal function of NTCp, and bile acids and their derivatives hold the potential for further development into antiviral drugs.
Journal ArticleDOI
Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide
Huan Yan,Bo Peng,Wenhui He,Guocai Zhong,Yonghe Qi,Bijie Ren,Zhenchao Gao,Zhiyi Jing,Mei Song,Guangwei Xu,Jianhua Sui,Wenhui Li +11 more
TL;DR: Understanding of NTCP-mediated viral entry of HBV and HDV and have important implications for developing the mouse model for their infections are advanced.
Journal ArticleDOI
DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.
Yonghe Qi,Zhenchao Gao,Guangwei Xu,Bo Peng,Chenxuan Liu,Huan Yan,Qiyan Yao,Guoliang Sun,Yang Liu,Dingbin Tang,Zilin Song,Wenhui He,Yinyan Sun,Ju-Tao Guo,Wenhui Li +14 more
TL;DR: DNA polymerase κ (POLK), a Y-family DNA polymerase with maximum activity in non-dividing cells, substantially contributes to cccDNA formation during de novo HBV infection, suggesting that POLK may be a potential target for developing antivirals against HBV.
Posted ContentDOI
The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
Brian D. Quinlan,Huihui Mou,Lizhou Zhang,Yan Guo,Wenhui He,Amrita Ojha,Mark S. Parcells,Guangxiang Luo,Wenhui Li,Guocai Zhong,Guocai Zhong,Hyeryun Choe,Michael Farzan +12 more
TL;DR: The data suggest that an RBD-based vaccine for SARS-CoV-2 could be safe and effective, and that anti-sera from immunized animals did not mediate antibody-dependent enhancement of S-protein-mediated entry under conditions in which Zika virus ADE was readily observed.