Wenrui Zheng

TL;DR: This work marks the first efficient asymmetric construction of optically enriched eight-membered rings by phosphine catalysis, in excellent yields and with nearly perfect enantioselectivities.

TL;DR: The first catalytic asymmetric synthesis of N–N axially chiral compounds has been accomplished via a quinidine catalyzed N-allylic alkylation reaction via DFT calculations to understand the origin of enantioselectivity and provide guidance for the design of additional molecules of this type.

TL;DR: Chiral phosphoric acid-catalyzed highly enantioselective formal [3 + 2] cycloaddition reaction of azoalkenes with 3-vinylindoles has been established and will empower asymmetric synthesis of nitrogen-containing ring structural motifs in a broader context.

TL;DR: The first phosphine-catalyzed enantioselective formal oxa-[4 + 2] reaction between nitroethylene and α-cyano-α,β-unsaturated ketones has been developed with excellent enantio- and diastereoselectivities.

TL;DR: A type of allenic ketone is introduced as a dielectrophilic C4 synthon in phosphine-mediated reactions to improve the electrophilicity of the advanced intermediates created upon phosphine activation.