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Wilfrid Richer
Researcher at Curie Institute
Publications - 26
Citations - 1217
Wilfrid Richer is an academic researcher from Curie Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 16, co-authored 23 publications receiving 841 citations. Previous affiliations of Wilfrid Richer include University of Évry Val d'Essonne & PSL Research University.
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Journal ArticleDOI
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.
François Le Loarer,François Le Loarer,Sarah Watson,Gaëlle Pierron,Vincent Thomas de Montpréville,Stelly Ballet,Nelly Firmin,Aurélie Auguste,Daniel Pissaloux,Sandrine Boyault,Sandrine Paindavoine,Pierre Joseph Dechelotte,Benjamin Besse,Benjamin Besse,Jean Michel Vignaud,Marie Brevet,Elie Fadel,Wilfrid Richer,Isabelle Treilleux,Julien Masliah-Planchon,Mojgan Devouassoux-Shisheboran,Gérard Zalcman,Yves Allory,Yves Allory,Franck Bourdeaut,Françoise Thivolet-Béjui,Dominique Ranchère-Vince,Nicolas Girard,Sylvie Lantuejoul,Françoise Galateau-Sallé,Jean Michel Coindre,Alexandra Leary,Olivier Delattre,Jean-Yves Blay,Jean-Yves Blay,Franck Tirode +35 more
TL;DR: Gene profiling analyses demonstrated that these tumors were distinct from lung carcinomas but related to MRTs and SCCOHTs, a new category of 'SMARCA4-deficient thoracic sarcomas' as readily recognizable in clinical practice, providing opportunities to tailor their therapeutic management.
Journal ArticleDOI
A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets.
Marion Salou,François Legoux,Jules Gilet,Aurélie Darbois,Anastasia du Halgouet,Ruby Alonso,Wilfrid Richer,Anne-Gaëlle Goubet,Celine Daviaud,Laurie Menger,Emanuele Procopio,Virginie Premel,Olivier Lantz,Olivier Lantz +13 more
TL;DR: First transcriptomic analysis of murine MAIT cells was performed, demonstrating that MAIT and NKT cells are resident in the spleen, liver, and lungs, with LFA1/ICAM1 interactions controlling MAIT1 and N KT1 retention in spleen and liver.
Journal ArticleDOI
Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma.
Mathieu Chicard,Sandrine Boyault,Leo Colmet Daage,Wilfrid Richer,David Gentien,Gaëlle Pierron,Eve Lapouble,Angela Bellini,Nathalie Clément,Isabelle Iacono,Stéphanie Bréjon,Marjorie Carrère,Cécile Reyes,Toby Dylan Hocking,Virginie Bernard,Michel Peuchmaur,Nadège Corradini,Cécile Faure-Conter,Carole Coze,Dominique Plantaz,Anne-Sophie Defachelles,Estelle Thebaud,Marion Gambart,Frédéric Millot,Dominique Valteau-Couanet,Jean Michon,Alain Puisieux,Olivier Delattre,Valérie Combaret,Gudrun Schleiermacher +29 more
TL;DR: The results demonstrate the feasibility of cfDNA copy number profiling in neuroblastoma patients, with a concordance of the overall genomic profile in aCGH and cfDNA dynamic cases of 97% and a sensitivity of 77%, respectively.
Journal ArticleDOI
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer
Rodrigo Nalio Ramos,Yoann Missolo-Koussou,Yohan Gerber-Ferder,Christian P. Bromley,Mattia Bugatti,Nicolás Gonzalo Núñez,Jimena Tosello Boari,Wilfrid Richer,Laurie Menger,Jordan Denizeau,Christine Sedlik,Pamela Caudana,Fiorella Kotsias,Leticia Laura Niborski,Sophie Viel,Mylène Bohec,Sonia Lameiras,Sylvain Baulande,Laëtitia Lesage,André Nicolas,Didier Meseure,Anne Vincent-Salomon,Fabien Reyal,Charles-Antoine Dutertre,Florent Ginhoux,Lene Vimeux,Emmanuel Donnadieu,Bénédicte Buttard,Jérôme Galon,Santiago Zelenay,William Vermi,Pierre Guermonprez,Eliane Piaggio,Julie Helft +33 more
TL;DR: In this article , a discrete population of FOLR2+ tissue-resident macrophages was identified in healthy mammary gland and breast cancer primary tumors, where they interacted with CD8+ T cells.
Journal ArticleDOI
Balanced Translocations Disrupting SMARCB1 Are Hallmark Recurrent Genetic Alterations in Renal Medullary Carcinomas.
Julien Calderaro,Julien Calderaro,Julien Masliah-Planchon,Wilfrid Richer,Laetitia Maillot,Pascale Maillé,Ludovic Mansuy,Claire Bastien,Alexandre de la Taille,Alexandre de la Taille,Helene Boussion,Cécile Charpy,Anne Jourdain,Claire Bléchet,Gaëlle Pierron,David Gentien,Laurence Choudat,Christophe Tournigand,Olivier Delattre,Yves Allory,Yves Allory,Franck Bourdeaut +21 more
TL;DR: A comprehensive molecular study supports a pivotal role of the tumor suppressor gene SMARCB1 in the development of renal medullary carcinoma and suggests the use of therapeutic strategies based on the biologic effects of its inactivation should now open new perspectives for this typically lethal malignancy.