W
Wilhelm Schäfer
Researcher at University of Hamburg
Publications - 101
Citations - 6867
Wilhelm Schäfer is an academic researcher from University of Hamburg. The author has contributed to research in topics: Virulence & Gene. The author has an hindex of 42, co-authored 101 publications receiving 6248 citations. Previous affiliations of Wilhelm Schäfer include Cornell University & University of Aberdeen.
Papers
More filters
Journal ArticleDOI
Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum
Carin Jansen,Diter von Wettstein,Wilhelm Schäfer,Karl-Heinz Kogel,Angelika Felk,Frank J. Maier +5 more
TL;DR: It is demonstrated that trichothecenes are not a virulence factor during infection through the fruit coat of Fusarium head blight, and the fungus is blocked by the development of heavy cell wall thickenings in the rachis node of Nandu wheat, a defense inhibited by the mycotoxin.
Journal ArticleDOI
A secreted lipase of Fusarium graminearum is a virulence factor required for infection of cereals.
TL;DR: Transformation-mediated disruption of FGL1 led to reduced extracellular lipolytic activity in culture and to reduced virulence to both wheat and maize, which allowed us to isolate, clone, and characterize a gene (FGL1) encoding a secreted lipase.
Journal ArticleDOI
Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.
Bernhard Hube,Dominique Sanglard,Frank C. Odds,Daniela Hess,Michel Monod,Wilhelm Schäfer,Alistair J. P. Brown,Neil A. R. Gow +7 more
TL;DR: The data suggest that SAP1, SAP2, and SAP3 all contribute to the overall virulence of C. albicans and presumably all play important roles during disseminated infections.
Journal ArticleDOI
Involvement of trichothecenes in fusarioses of wheat, barley and maize evaluated by gene disruption of the trichodiene synthase (Tri5) gene in three field isolates of different chemotype and virulence.
Frank J. Maier,Thomas Miedaner,Birgit Hadeler,Angelika Felk,Siegfried Salomon,Marc Lemmens,Helmut Kassner,Wilhelm Schäfer +7 more
TL;DR: It is demonstrated that trichothecenes influence the virulence of F. graminearum in a highly complex manner, which is strongly host as well as moderately chemotype specific.
Journal ArticleDOI
Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs
Angelika Felk,Angelika Felk,Marianne Kretschmar,Antje Albrecht,Martin Schaller,Sabine Beinhauer,Thomas Nichterlein,Dominique Sanglard,Hans C. Korting,Wilhelm Schäfer,Bernhard Hube,Bernhard Hube +11 more
TL;DR: It can be concluded that the reduced virulence of hypha-deficient mutants is not only due to the inability to form hyphae but also due to modified expression of the SAP genes normally associated with the hyphal morphology, particularly that encoded by SAP6.