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Michel Monod

Researcher at University Hospital of Lausanne

Publications -  239
Citations -  16573

Michel Monod is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Aspergillus fumigatus & Gene. The author has an hindex of 61, co-authored 230 publications receiving 15251 citations. Previous affiliations of Michel Monod include Centre national de la recherche scientifique & University of Lausanne.

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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

William C. Nierman, +120 more
- 22 Dec 2005 - 
TL;DR: The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.

TL;DR: It is found that overexpression of the gene encoding 14DM either by gene amplification or by gene deregulation was not the major cause of resistance among these clinical isolates of fluconazole-resistant C. albicans, and that resistance could be mediated by energy-requiring efflux pumps such as ATP-binding cassette (ABC) multidrug transporters.
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Candida colonization and subsequent infections in critically ill surgical patients.

TL;DR: The intensity of Candida colonization assessed by systematic screening helps predicting subsequent infections with identical strains in critically ill patients, and offers opportunity for intervention strategies.
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Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

TL;DR: Data demonstrate that CDR2 plays an important role in mediating the resistance of C. albicans to azole antifungal agents.