L
Liming Pei
Researcher at Children's Hospital of Philadelphia
Publications - 38
Citations - 5700
Liming Pei is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Liver X receptor & Nuclear receptor. The author has an hindex of 27, co-authored 38 publications receiving 5009 citations. Previous affiliations of Liming Pei include Salk Institute for Biological Studies & University of California, Los Angeles.
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Journal ArticleDOI
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Sean B. Joseph,Elaine McKilligin,Liming Pei,Michael A. Watson,Alan R. Collins,Bryan A. Laffitte,Mingyi Chen,Grace Noh,Joanne Goodman,Graham N. Hagger,Jonathan Tran,Tim K. Tippin,Xuping Wang,Aldons J. Lusis,Willa A. Hsueh,Ronald E. Law,Jon L. Collins,Timothy M. Willson,Peter Tontonoz +18 more
TL;DR: It is demonstrated here that the nonsteroidal LXR agonist GW3965 has potent antiatherogenic activity in two different murine models, providing direct evidence for an atheroprotective effect of LXRs agonists and support their further evaluation as potential modulators of human cardiovascular disease.
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Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP
Jiandie D. Lin,Ruojing Yang,Paul T. Tarr,Pei Hsuan Wu,Christoph Handschin,Siming Li,Wenli Yang,Liming Pei,Marc Uldry,Peter Tontonoz,Christopher B. Newgard,Bruce M. Spiegelman +11 more
TL;DR: It is shown here that high-fat feeding, which induces hyperlipidemia and atherogenesis, stimulates the expression of both PGC-1beta and SREBP1c and 1a in liver, suggesting a mechanism through which dietary saturated fats can stimulate hyperlipIDemia and Atherogenesis.
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LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response
Sean B. Joseph,Michelle N. Bradley,Antonio Castrillo,Kevin W. Bruhn,Puiying A. Mak,Liming Pei,John B. Hogenesch,Ryan M. O'Connell,Genhong Cheng,Enrique Saez,Jeffery F. Miller,Peter Tontonoz +11 more
TL;DR: The results demonstrate that LXR-dependent gene expression plays an unexpected role in innate immunity and suggest that common nuclear receptor pathways mediate macrophage responses to modified lipoproteins and intracellular pathogens.
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Autoregulation of the Human Liver X Receptor α Promoter
Bryan A. Laffitte,Sean B. Joseph,Robert Walczak,Liming Pei,Damien C. Wilpitz,Jon L. Collins,Peter Tontonoz,Peter Tontonoz +7 more
TL;DR: It is demonstrated here that autoregulation of the LXRα gene is an important component of this lipid-inducible efflux pathway in human macrophages and its potential to be regulated by synthetic LXR and/or PPARγ ligands.
Journal ArticleDOI
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
Liming Pei,Hironori Waki,Bhavapriya Vaitheesvaran,Damien C. Wilpitz,Irwin J. Kurland,Peter Tontonoz +5 more
TL;DR: It is shown that members of the NR4A family of ligand-independent orphan nuclear receptors are downstream mediators of cAMP action in the hormonal control of gluconeogenesis and outline a previously unrecognized role for orphan nuclear receptor in the transcriptional control of glucose homeostasis.