Christopher J. Lyon

TL;DR: How adipose tissue becomes inflamed in obesity is described, ways these mechanisms impact cancer development are summarized, and their role in four adipose-associated cancers that demonstrate elevated incidence or mortality in obesity are discussed.

TL;DR: Investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM M HCII, escalates its progression.

TL;DR: A rapid, ultrasensitive and inexpensive nanoplasmon-enhanced scattering (nPES) assay that directly quantifies tumor-derived EVs from as little as 1 μL of plasma, and identifies a pancreatic cancer EV biomarker, ephrin type-A receptor 2 (EphA2), and demonstrates that an nPES assay for EphA 2-EVs distinguishes pancreaticcancer patients from pancreatitis patients and healthy subjects.

TL;DR: This assay utilizes a custom CRISPR Cas12a/gRNA complex and a fluorescent probe to amplify target amplicons produced by standard RT-PCR or isothermal recombinase polymerase amplification (RPA) to allow sensitive detection at sites not equipped with real-time PCR systems required for qPCR diagnostics.

TL;DR: The mechanism for the accelerated vascular injury in older LDLR−/− mice was likely the profound inability to mount an antioxidant response, and the need to develop effective strategies to inhibit oxidative stress to protect aging vasculature is emphasized.