William A. Hanlon

TL;DR: Although the overall pattern of protein expression is similar to that of mRNA expression, the incongruent expression between mRNAs and proteins emphasize the importance of posttranscriptional regulatory mechanisms in cellular development or perturbation that can be unveiled only through integrated analyses of both proteins and m RNAs.

TL;DR: Data suggest that signal transduction as a result of clustering L-selectin utilizes p38 MAPK to effect neutrophil shape change, integrin activation, and the release of secondary, tertiary, and secretory granules.

TL;DR: Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-p Pyrroles as potent, orally bioavailable inhibitors of p38 kinase.

TL;DR: P38 functions in PMN to signal leukocyte integrin-dependent adhesion and the subsequent massive production of reactive oxygen intermediates, suggesting that p38 kinase activity was required throughout the lag but not after the oxidase was assembled.

TL;DR: The data in this report suggest that the mechanism by which L‐790,070 blocked monocyte differentiation and prevented chemotaxis was by inhibiting p38 MAP kinase activity.