M
Matthew J. Kostura
Researcher at Merck & Co.
Publications - 22
Citations - 4349
Matthew J. Kostura is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 10, co-authored 14 publications receiving 4182 citations.
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Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
Identification of a monocyte specific pre-interleukin 1 beta convertase activity
Matthew J. Kostura,Michael J. Tocci,Guadalupe A. Limjuco,Jayne Chin,Patricia M. Cameron,Andrew G. Hillman,Nicole A. Chartrain,John A. Schmidt +7 more
TL;DR: In this paper, the authors showed that only extracts derived from human monocytes and THP.1 cells were capable of cleaving precursor IL-1 beta to authentic mature IL 1 β.
Journal ArticleDOI
Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice
Hui Zheng,Daniel S. Fletcher,Wieslaw Kozak,Minghao Jiang,Kathryn J. Hofmann,Carole A. Corn,Darlusz Soszynski,Christina Grabiec,Myrna E. Trumbauer,Alan Shaw,Matthew J. Kostura,Karla Stevens,Hugh Rosen,Robert J. North,Howard Y. Chen,Michael J. Tocci,Matthew J. Kluger,Lex H.T. Van der Ploeg +17 more
TL;DR: A central role for IL-1 beta as a pyrogen and a mediator of the acute-phase response in a subset of inflammatory disease models is highlighted, and the notion that blocking the action of a single key cytokine can alter the course of specific immune and inflammatory responses is supported.
Journal Article
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
Andrew D. Howard,Matthew J. Kostura,Nancy A. Thornberry,Gloria J.-F. Ding,Guadalupe A. Limjuco,Jeffrey R. Weidner,J P Salley,Kristin A. Hogquist,David D. Chaplin,David D. Chaplin,Richard A. Mumford +10 more
TL;DR: Results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P2', and not like any other eukaryotic protease.
Journal ArticleDOI
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.
Irwin I. Singer,S Scott,Jayne Chin,Ellen K. Bayne,Guadalupe A. Limjuco,Jeffrey R. Weidner,Douglas K. Miller,Kevin T. Chapman,Matthew J. Kostura +8 more
TL;DR: The data suggests that mature IL-1 beta is generated via cleavage of the 31-kD inactive cytoplasmic IL- 1 beta precursor by ICE after association with the plasma membrane during secretion.