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William G. H. Abbott
Researcher at Auckland City Hospital
Publications - 33
Citations - 964
William G. H. Abbott is an academic researcher from Auckland City Hospital. The author has contributed to research in topics: Hepatitis B & Hepatitis B virus. The author has an hindex of 12, co-authored 33 publications receiving 888 citations. Previous affiliations of William G. H. Abbott include Southern Medical University & University of Auckland.
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Journal ArticleDOI
Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers
Alexander J. Thompson,Tin Nguyen,D. Iser,D. Iser,Anna Ayres,Kathy Jackson,Margaret Littlejohn,John Slavin,Scott Bowden,Edward Gane,William G. H. Abbott,George K. K. Lau,Sharon R Lewin,Sharon R Lewin,Sharon R Lewin,Kumar Visvanathan,Kumar Visvanathan,Paul V. Desmond,Stephen Locarnini +18 more
TL;DR: The correlation between quantitative HBsAg titer and serum and intrahepatic markers of HBV replication differs between patients with H beAg‐positive and HBeAg‐negative CHB, providing new insights into viral pathogenesis and have practical implications for the use of quantitative serology as a clinical biomarker.
Journal ArticleDOI
High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B
Shiwu Ma,Xuan Huang,Yongyin Li,Libo Tang,Xiao-Feng Sun,Xiaotao Jiang,Yue-xin Zhang,Jian Sun,Zhihua Liu,William G. H. Abbott,William G. H. Abbott,Yuhong Dong,Nikolai V. Naoumov,Jinlin Hou +13 more
TL;DR: Serum IL-21 levels may be a biomarker for HBeAg seroconversion, and may contribute to individualization of antiviral therapy in H beAg-positive chronic hepatitis B (CHB) patients undergoing telbivudine treatment.
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Circulating chemokine (C-X-C Motif) receptor 5(+) CD4(+) T cells benefit hepatitis B e antigen seroconversion through IL-21 in patients with chronic hepatitis B virus infection.
Yongyin Li,Shiwu Ma,Libo Tang,Yun Li,Wei Wang,Xuan Huang,Qintao Lai,Mingxia Zhang,Jian Sun,Chris Ka-fai Li,William G. H. Abbott,Nikolai V. Naoumov,Yu Zhang,Jinlin Hou +13 more
TL;DR: Circulating CXCR5+CD4+ T cells, by producing IL‐21, may have a significant role in facilitating HBeAg seroconversion in patients with chronic HBV infection.
Journal ArticleDOI
Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease.
Xiao-Min Hu,S. Ma,X. Huang,X. Jiang,X. Zhu,H. Gao,M. Xu,J. Sun,William G. H. Abbott,William G. H. Abbott,Jinlin Hou +10 more
TL;DR: IL‐21 has a causal role in the development of severe liver inflammation, which is upregulated in HB‐ACLF and associated with severity of liver disease.
Journal ArticleDOI
Restored circulating invariant NKT cells are associated with viral control in patients with chronic hepatitis B.
Xiao-Tao Jiang,Mingxia Zhang,Qintao Lai,Xuan Huang,Yongyin Li,Jian Sun,William G. H. Abbott,William G. H. Abbott,Shiwu Ma,Jinlin Hou +9 more
TL;DR: There is a low frequency of peripheral iNKT cells in chronic hepatitis B patients, which increases to normal levels with viral control, and the ratio of CD4−/CD4+ iN KT cells at baseline may be a useful predictor for HBeAg seroconversion in CHB patients on telbivudine therapy.