Journal ArticleDOI
Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix
William A. Peters,P. Y. Liu,Rolland J. Barrett,Richard J. Stock,Bradley J. Monk,Jonathan S. Berek,Luis Souhami,Perry Grigsby,William Gordon,David S. Alberts +9 more
TLDR
The addition of concurrent cisplatin-based CT to RT significantly improves progression-free and overall survival for high-risk, early-stage patients who undergo radical hysterectomy and pelvic lymphadenectomy for carcinoma of the cervix.Abstract:
PURPOSE: To determine whether the addition of cisplatin-based chemotherapy (CT) to pelvic radiation therapy (RT) will improve the survival of early-stage, high-risk patients with cervical carcinoma. PATIENTS AND METHODS: Patients with clinical stage IA2, IB, and IIA carcinoma of the cervix, initially treated with radical hysterectomy and pelvic lymphadenectomy, and who had positive pelvic lymph nodes and/or positive margins and/or microscopic involvement of the parametrium were eligible for this study. Patients were randomized to receive RT or RT + CT. Patients in each group received 49.3 GY RT in 29 fractions to a standard pelvic field. Chemotherapy consisted of bolus cisplatin 70 mg/m2 and a 96-hour infusion of fluorouracil 1,000 mg/m2/d every 3 weeks for four cycles, with the first and second cycles given concurrent to RT. RESULTS: Between 1991 and 1996, 268 patients were entered onto the study. Two hundred forty-three patients were assessable (127 RT + CT patients and 116 RT patients). Progression-fre...read more
Citations
More filters
Journal ArticleDOI
Nanotechnology for Multimodal Synergistic Cancer Therapy
TL;DR: In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergy therapy.
Journal ArticleDOI
Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis
John Green,John M. Kirwan,Jayne F. Tierney,P. Symonds,Lydia L Fresco,M Collingwood,Chris Williams +6 more
TL;DR: Concomitant chemotherapy and radiotherapy improves overall and progression-free survival and reduces local and distant recurrence in selected patients with cervical cancer, which may give a cytotoxic and sensitisation effect.
Journal ArticleDOI
Pelvic Irradiation With Concurrent Chemotherapy Versus Pelvic and Para-Aortic Irradiation for High-Risk Cervical Cancer: An Update of Radiation Therapy Oncology Group Trial (RTOG) 90-01
Patricia J. Eifel,Kathryn Winter,Mitchell Morris,Charles F Levenback,Perry W. Grigsby,Jay S. Cooper,Marvin Rotman,David M. Gershenson,David G. Mutch +8 more
TL;DR: In this article, the authors report mature results of a randomized trial that compared EFRT versus pelvic radiotherapy with concomitant fluorouracil and cisplatin (CTRT) in women with locoregionally advanced carcinomas of the uterine cervix.
Journal ArticleDOI
Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials
Claire L Vale,Jayne F. Tierney,Lesley A. Stewart,Mark F. Brady,Ketayun A. Dinshaw,Anders Jakobsen,Mahesh K. B. Parmar,Gillian Thomas,Ted Trimble,David S. Alberts,Hongwei Chen,Slobodan Cikaric,Patricia J. Eifel,Melahat Garipagaoglu,Henry M. Keys,Nermina Kantardzic,Punita Lal,Rachelle Lanciano,Felix Leborgne,Vicharn Lorvidhaya,Hiroshi Onishi,Robert Pearcey,E Pras,Kenneth B. Roberts,Peter G. Rose,Charles W. Whitney +25 more
TL;DR: These results endorse the recommendations of the NCI alert, but also demonstrate their applicability to all women and a benefit of non-platinum-based chemoradiotherapy.
References
More filters
Journal ArticleDOI
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Peter G. Rose,Brian N. Bundy,E B Watkins,J T Thigpen,G Deppe,M A Maiman,Daniel L. Clarke-Pearson,S Insalaco +7 more
TL;DR: Regimens of radiotherapy and chemotherapy that contain cisplatin improve the rates of survival and progression-free survival among women with locally advanced cervical cancer.
Journal ArticleDOI
Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer.
Mitchell Morris,Patricia J. Eifel,Jiandong Lu,Perry W. Grigsby,Charles F Levenback,Randy Stevens,Marvin Rotman,David M. Gershenson,David G. Mutch +8 more
TL;DR: The addition of chemotherapy with fluorouracil and cisplatin to treatment with external-beam and intracavitary radiation significantly improved survival among women with locally advanced cervical cancer.
Journal ArticleDOI
Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma
Henry M. Keys,Brian N. Bundy,Frederick B. Stehman,Laila I. Muderspach,Weldon E. Chafe,Charles L. Suggs,Joan L. Walker,Deborah Gersell +7 more
TL;DR: Adding weekly infusions of cisplatin to pelvic radiotherapy followed by hysterectomy significantly reduced the risk of disease recurrence and death in women with bulky stage IB cervical cancers.
Journal ArticleDOI
Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer
Fabio Landoni,Andrea Maneo,Alessandro Colombo,Franco Placa,Rodolfo Milani,Patrizia Perego,Giorgio Favini,Luigi Ferri,Costantino Mangioni +8 more
TL;DR: There is no treatment of choice for early-stage cervical carcinoma in terms of overall or disease-free survival and the combination of surgery and radiotherapy has the worst morbidity, especially urological complications.
Journal ArticleDOI
Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study
Charles W. Whitney,William T. Sause,Brian N. Bundy,John H. Malfetano,Edward V. Hannigan,Wesley C. Fowler,Daniel L. Clarke-Pearson,Shu Yuan Liao +7 more
TL;DR: This study demonstrates that for patients with locally advanced carcinoma of the cervix, the combination of 5-FU and CF with RT offers patients better PFS and overall survival than HU, and with manageable toxicity.