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William J. Tremaine
Researcher at Mayo Clinic
Publications - 290
Citations - 26053
William J. Tremaine is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 80, co-authored 282 publications receiving 24233 citations. Previous affiliations of William J. Tremaine include University of Paris & Cedars-Sinai Medical Center.
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Journal ArticleDOI
Validation of the ulcerative colitis colonoscopic index of severity and its correlation with disease activity measures.
Sunil Samuel,Sunil Samuel,David H. Bruining,Edward V. Loftus,Kelvin T. Thia,Kenneth W. Schroeder,William J. Tremaine,William A. Faubion,Sunanda V. Kane,Darrell S. Pardi,Piet C. de Groen,William S. Harmsen,Alan R. Zinsmeister,William J. Sandborn +13 more
TL;DR: The previously developed UC Colonoscopic Index of Severity (UCCIS) is a simple tool that provides reproducible results in endoscopic scoring of patients with UC and is validated by a rederivation of the equation for the UCCIS.
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Primary sclerosing cholangitis is associated with nonsmoking: A case- control study
Edward V. Loftus,William J. Sandborn,William J. Tremaine,Douglas W. Mahoney,Alan R. Zinsmeister,Kenneth P. Offord,LJ Melton +6 more
TL;DR: The odds of having primary sclerosing cholangitis was significantly decreased among current smokers, suggesting that smoking may exert its protective effect in a systemic, rather than colonic, manner.
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Successful management of Crohn's disease of the ileoanal pouch with infliximab.
TL;DR: It is demonstrated that the murine chimeric anti-TNF-alpha monoclonal antibody, infliximab, can be used successfully to treat patients with Crohn's disease involving an IPAA who are refractory to conventional therapies.
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Prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease detected with CT enterography
David H. Bruining,Hassan Siddiki,Joel G. Fletcher,William J. Tremaine,William J. Sandborn,Edward V. Loftus +5 more
TL;DR: CT enterography is a valuable diagnostic modality for detecting both penetrating disease and extraintestinal IBD manifestations of Crohn's disease and this data adds to a growing body of evidence that supports the use of CTE in CD diagnostic and management algorithms.
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Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine
TL;DR: Many patients with microscopic colitis will respond to antidiarrheal medications or to anti-inflammatory therapy with 5-aminosalicylates, although a few require corticosteroids, and a small subset are dependent on or refractory to cortICosteroids.