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William K. M. Lai
Researcher at Cornell University
Publications - 33
Citations - 1098
William K. M. Lai is an academic researcher from Cornell University. The author has contributed to research in topics: Promoter & Chromatin. The author has an hindex of 17, co-authored 30 publications receiving 866 citations. Previous affiliations of William K. M. Lai include University at Buffalo & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Understanding nucleosome dynamics and their links to gene expression and DNA replication.
TL;DR: Nucleosome dynamics are governed by a complex interplay of histone composition, histone post-translational modifications, nucleosome occupancy and positioning within chromatin, which are influenced by numerous regulatory factors, including general Regulatory factors, chromatin remodellers, chaperones and polymerases.
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A high-resolution protein architecture of the budding yeast genome.
Matthew J. Rossi,Prashant K. Kuntala,William K. M. Lai,William K. M. Lai,Naomi Yamada,Nitika Badjatia,Chitvan Mittal,Chitvan Mittal,Guray Kuzu,Kylie Bocklund,Nina Farrell,Thomas R. Blanda,Joshua Mairose,Ann V. Basting,Katelyn Mistretta,David J. Rocco,Emily S. Perkinson,Gretta Kellogg,Gretta Kellogg,Shaun Mahony,B. Franklin Pugh,B. Franklin Pugh +21 more
TL;DR: In this paper, the authors identify 21 meta-assemblages consisting of roughly 400 different proteins that are related to DNA replication, centromeres, subtelomeres, transposons and transcription by RNA polymerase (Pol) I, II and III.
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Simplified ChIP-exo assays.
TL;DR: Greater library yields, lower processing time, and lower costs are achieved through assay optimization and use of Tn5 tagmentation and/or single-stranded DNA ligation in the greatly simplified ChIP-exo methods.
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Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.
Richard R. Almon,Eric Yang,William K. M. Lai,Ioannis P. Androulakis,Svetlana Ghimbovschi,Eric P. Hoffman,William J. Jusko,Debra C. DuBois +7 more
TL;DR: Examination of transcription factors involved in circadian control suggests that corticosterone may be the initiator of their rhythmic expression patterns in skeletal muscle.
Journal ArticleDOI
Circadian variations in rat liver gene expression: relationships to drug actions.
Richard R. Almon,Eric Yang,William K. M. Lai,Ioannis P. Androulakis,Debra C. DuBois,William J. Jusko +5 more
TL;DR: It is hypothesized that global gene expression analysis can be useful in the identification of circadian-regulated genes involved in drug action, and data suggest that these genes may also be regulated by corticosteroids.