W
William R. Gray
Researcher at University of Utah
Publications - 76
Citations - 8633
William R. Gray is an academic researcher from University of Utah. The author has contributed to research in topics: Peptide sequence & Conotoxin. The author has an hindex of 50, co-authored 76 publications receiving 8440 citations. Previous affiliations of William R. Gray include University of the Philippines Diliman & University of Debrecen.
Papers
More filters
Journal ArticleDOI
Peptide neurotoxins from fish-hunting cone snails
Baldomero M. Olivera,William R. Gray,R Zeikus,J M McIntosh,J Varga,Jean Rivier,V de Santos,Lourdes J. Cruz +7 more
TL;DR: Five new omega-conotoxins that block presynaptic calcium channels are described, and the fact that they inhibit sequential steps in neuromuscular transmission suggests that their action is synergistic rather than additive.
Journal ArticleDOI
A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors
G. Edward Cartier,Doju Yoshikami,William R. Gray,Siqin Luo,Baldomero M. Olivera,J. Michael McIntosh +5 more
TL;DR: A 16-amino acid peptide from the venom of the marine snail Conus magus was identified by electrophysiologically screening venom fractions against cloned nicotinic receptors expressed in Xenopus oocytes.
Journal ArticleDOI
Purification and sequence of a presynaptic peptide toxin from Conus geographus venom.
TL;DR: A novel toxin, omega-conotoxin (omega-CgTX), from the venom of the fish-eating marine mollusc Conus geographus has been purified and biochemically characterized, providing a potentially powerful probe for exploring the vertebrate presynaptic terminal.
Journal ArticleDOI
Conus geographus toxins that discriminate between neuronal and muscle sodium channels.
Lourdes J. Cruz,William R. Gray,Baldomero M. Olivera,R D Zeikus,Lynne M. Kerr,Doju Yoshikami,Edward Moczydlowski +6 more
TL;DR: Using the major peptide (GIIIA) in electrophysiological studies on nerve-muscle preparations and in single channel studies using planar lipid bilayers, it is established that the toxin blocks muscle sodium channels, while having no discernible effect on nerve or brain sodium channels.
Journal ArticleDOI
Molecular Model for Elastin Structure and Function
TL;DR: Amino acid sequences in elastin contain striking patterns, and an ‘oiled coil’ model is proposed to explain the protein's elastic behaviour.