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Wilmara Salgado-Pabón
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 40
Citations - 1956
Wilmara Salgado-Pabón is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Staphylococcus aureus & Superantigen. The author has an hindex of 20, co-authored 35 publications receiving 1585 citations. Previous affiliations of Wilmara Salgado-Pabón include University of Iowa & University of Wisconsin-Madison.
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Journal ArticleDOI
Staphylococcal and Streptococcal Superantigen Exotoxins
Adam R. Spaulding,Wilmara Salgado-Pabón,Petra L. Kohler,Alexander R. Horswill,Donald Y.M. Leung,Patrick M. Schlievert,Patrick M. Schlievert +6 more
TL;DR: The review discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses.
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Models matter: the search for an effective Staphylococcus aureus vaccine
TL;DR: It is suggested that an over-reliance on rodent models and a focus on targeting cell surface components have been major contributing factors to this failure of S. aureus vaccine trials.
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Superantigens Are Critical for Staphylococcus aureus Infective Endocarditis, Sepsis, and Acute Kidney Injury
Wilmara Salgado-Pabón,Laura M. Breshears,Adam R. Spaulding,Joseph A. Merriman,Christopher S. Stach,Alexander R. Horswill,Marnie L. Peterson,Patrick M. Schlievert +7 more
TL;DR: It is shown in the methicillin-resistant S. aureus strain MW2 that lethal sepsis, infective endocarditis, and kidney infections in rabbits are critically dependent on high-level SAgs, and superantigens are critical in the causation of all three infections.
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The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression
Heidi A. Crosby,Patrick M. Schlievert,Joseph A. Merriman,Jessica M. King,Wilmara Salgado-Pabón,Alexander R. Horswill +5 more
TL;DR: It is shown that mgrA mutants are less virulent in a rabbit model of endocarditis, and virulence can be partially restored by deleting the genes for the surface proteins ebh, sraP, and sasG, which are important for virulence.
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Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective Immunity
Gernot Sellge,Joao G. Magalhaes,Christoph Konradt,Jörg H. Fritz,Wilmara Salgado-Pabón,Gérard Eberl,Antonio Bandeira,James P. Di Santo,James P. Di Santo,Phillippe J. Sansonetti,Armelle Phalipon +10 more
TL;DR: It is shown that the elicited S. flexneri-specific Th17 pool gives rise to an enhanced recall response up to 12 mo after priming, suggesting the presence of a long-term memory state, bringing new insights into the adaptive immune response to Shigella infection and highlighting the importance of pathogen- specific Th17 cell immunity for secondary immune protection.