W
Wim F.A. Steelant
Researcher at New Mexico Institute of Mining and Technology
Publications - 35
Citations - 2878
Wim F.A. Steelant is an academic researcher from New Mexico Institute of Mining and Technology. The author has contributed to research in topics: Integrin & Cancer. The author has an hindex of 23, co-authored 35 publications receiving 2702 citations. Previous affiliations of Wim F.A. Steelant include Ghent University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
Veerle Noë,Barbara Fingleton,Kathleen Jacobs,Howard C. Crawford,Stefan Vermeulen,Wim F.A. Steelant,Erik Bruyneel,Lynn M. Matrisian,Marc Mareel +8 more
TL;DR: The results suggest a novel mechanism by which metalloproteinases can influence invasion, as indicated by induction of invasion into collagen type I and inhibition of E-cadherin-dependent cell aggregation.
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Versatile photosensitizers for photodynamic therapy at infrared excitation.
TL;DR: A new type of photosensitizers used in photodynamic therapy, which is based on photon upconverting nanoparticles, is reported that is excitable with infrared irradiation, which has several times larger tissue penetration depth than the currently available ones.
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Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones
Igor V. Magedov,Igor V. Magedov,Madhuri Manpadi,Marcia A. Ogasawara,Adriana S. Dhawan,Snezna Rogelj,Severine Van slambrouck,Wim F.A. Steelant,Nikolai M. Evdokimov,Pavel Y. Uglinskii,Eerik M. Elias,Erica J. Knee,Paul Tongwa,Mikhail Yu. Antipin,Mikhail Yu. Antipin,Alexander Kornienko +15 more
TL;DR: These heterocyclic libraries are expected to provide promising new leads in anticancer drug design and display low nanomolar antiproliferative activity and induce apoptosis in human cancer cell lines.
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Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis
Igor V. Magedov,Madhuri Manpadi,Severine Van slambrouck,Wim F.A. Steelant,Elena Rozhkova,Nikolai M Przheval'skii,Snezna Rogelj,Alexander Kornienko +7 more
TL;DR: The presented library of dihydropyridopyrazoles promising new leads in anticancer drug design is prepared by a straightforward one-step multicomponent synthesis and demonstrated to display antiproliferative properties in a number of human cancer cell lines.
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Tetraspanin CD9 Is a “Proteolipid,” and Its Interaction with α3 Integrin in Microdomain Is Promoted by GM3 Ganglioside, Leading to Inhibition of Laminin-5-dependent Cell Motility
Yasushi Kawakami,Kumiko Kawakami,Wim F.A. Steelant,Wim F.A. Steelant,Masaya Ono,Masaya Ono,Rena C. Baek,Kazuko Handa,Donald A. Withers,Sen-itiroh Hakomori,Sen-itiroh Hakomori +10 more
TL;DR: The results suggest that GM3 synthesized under +Gal condition promotes interaction of α3 with CD9, which restricts α3 binding to its antibody, which suggests that CD9 recruits α3 in GEM under + Gal condition, whereby GM3 is present.