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Barbara Fingleton
Researcher at Vanderbilt University
Publications - 104
Citations - 13537
Barbara Fingleton is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 46, co-authored 96 publications receiving 12717 citations. Previous affiliations of Barbara Fingleton include Northwestern University & Dublin City University.
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Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
TL;DR: The studies that brought MPIs into clinical testing are reviewed and the design and outcome of the trials are discussed in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression.
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Matrix Metalloproteinases: Biologic Activity and Clinical Implications
TL;DR: The preclinical and clinical evolution of the synthetic MMP inhibitors (MMPIs) is examined, with the discussion encompassing important methodologic issues associated with determining clinical efficacy of MMPIs and other novel therapeutic agents.
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Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
Li Yang,Laura Debusk,Koari Fukuda,Barbara Fingleton,Brenda Green-Jarvis,Yu Shyr,Lynn M. Matrisian,David P. Carbone,P. Charles Lin +8 more
TL;DR: Evidence is provided that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs.
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The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
Howard C. Crawford,Barbara Fingleton,Laura A. Rudolph-Owen,Kathleen J. Heppner Goss,Kathleen J. Heppner Goss,Bonnee Rubinfeld,Paul Polakis,Lynn M. Matrisian +7 more
TL;DR: It is proposed that regulation of matrilysin production by β-catenin accumulation is a contributing factor to intestinal tumorigenesis.
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Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
Veerle Noë,Barbara Fingleton,Kathleen Jacobs,Howard C. Crawford,Stefan Vermeulen,Wim F.A. Steelant,Erik Bruyneel,Lynn M. Matrisian,Marc Mareel +8 more
TL;DR: The results suggest a novel mechanism by which metalloproteinases can influence invasion, as indicated by induction of invasion into collagen type I and inhibition of E-cadherin-dependent cell aggregation.