W
Wito Richter
Researcher at University of South Alabama
Publications - 48
Citations - 3311
Wito Richter is an academic researcher from University of South Alabama. The author has contributed to research in topics: Phosphodiesterase & Receptor. The author has an hindex of 25, co-authored 47 publications receiving 3029 citations. Previous affiliations of Wito Richter include Leipzig University & University of California, Berkeley.
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Journal ArticleDOI
Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias
Stephan E. Lehnart,Xander H.T. Wehrens,Steven Reiken,Sunita Warrier,Andriy E. Belevych,Robert D. Harvey,Wito Richter,S.-L. Catherine Jin,Marco Conti,Andrew R. Marks +9 more
TL;DR: It is shown that PDE4D gene inactivation in mice results in a progressive cardiomyopathy, accelerated heart failure after myocardial infarction, and cardiac arrhythmias, and data suggest that reduced PDE 4D activity causes defective RyR2-channel function associated with heart failure and arrh rhythmias.
Journal ArticleDOI
Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.
Journal ArticleDOI
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
TL;DR: The results indicate that a better definition of the pattern of PDE4 expression is required for target validation, and multiple variants co-migrate in single immunoreactive bands, and variant-selective antibodies were necessary to discriminate between splice variants.
Journal ArticleDOI
Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes
Jérôme Leroy,Aniella Abi-Gerges,Viacheslav O. Nikolaev,Wito Richter,Patrick Lechêne,Jean-Luc Mazet,Marco Conti,Rodolphe Fischmeister,Grégoire Vandecasteele +8 more
TL;DR: CAMP-PDE assay on ARVMs briefly exposed to isoprenaline showed a pronounced (up to ≈50%) dose-dependent increase in total PDE activity, which was mainly attributable to activation of PDE4.
Journal ArticleDOI
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
Wito Richter,Peter Day,Rani Agrawal,Matthew D. Bruss,Sébastien Granier,Yvonne L Wang,Søren G. F. Rasmussen,Kathleen Horner,Ping Wang,Tao Lei,Andrew J. Patterson,Brian K. Kobilka,Marco Conti +12 more
TL;DR: It is proposed that the distinct modes of interaction with PDEs result in divergent cAMP signals in the vicinity of the two receptors, thus, providing an additional layer of complexity to enforce the specificity of β1‐ and β2‐adrenoceptor signaling.