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Witoon Tirasophon
Researcher at Mahidol University
Publications - 22
Citations - 1932
Witoon Tirasophon is an academic researcher from Mahidol University. The author has contributed to research in topics: Endoplasmic reticulum & Unfolded protein response. The author has an hindex of 13, co-authored 22 publications receiving 1813 citations. Previous affiliations of Witoon Tirasophon include University of Michigan.
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Journal ArticleDOI
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
Kyungho Lee,Witoon Tirasophon,Xiaohua Shen,Marek Michalak,Ron Prywes,Tetsuya Okada,Hiderou Yoshida,Kazutoshi Mori,Randal J. Kaufman +8 more
TL;DR: It is proposed that nuclear- localized IRE1alpha and cytoplasmic-localized ATF6 signaling pathways merge through regulation of XBP1 activity to induce downstream gene expression.
Journal ArticleDOI
YHV-protease dsRNA inhibits YHV replication in Penaeus monodon and prevents mortality.
TL;DR: Penaeus monodon possesses the sequence-specific protection to YHV infection, most likely through the RNAi pathway, in addition to sequence-independent protection, a new notion that dsRNA induction of antiviral immunity in shrimp goes through two pathways, sequence- independent and sequence-dependent.
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Silencing of yellow head virus replication in penaeid shrimp cells by dsRNA.
TL;DR: These findings are the first evidence that RNAi-mediated gene silencing is operative in shrimp cells, and could be a powerful tool for studying gene function and to develop effective control of viral infection in shrimp.
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Protein Serine/Threonine Phosphatase Ptc2p Negatively Regulates the Unfolded-Protein Response by Dephosphorylating Ire1p Kinase
TL;DR: It is demonstrated that Ptc2p downregulates the UPR by dephosphorylating Ire1p and reveal a novel mechanism of regulation in theUPR pathway upstream of the HAC1 mRNA splicing event.
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Therapeutic inhibition of yellow head virus multiplication in infected shrimps by YHV-protease dsRNA
TL;DR: It is demonstrated that YHV-protease dsRNA gives therapeutic effect and pave the way to develop a cure for YhV-infected shrimps.