Chulhee Choi

TL;DR: Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cγ1, and subsequently increased cell proliferation and migration in response to PDGF, demonstrating a localized role for endogenous H2 O2 in PDGF signalling, and indicating a biological function of Prx II in cardiovascular disease.

TL;DR: A new tool for intracellular delivery of target proteins, named ‘exosomes for protein loading via optically reversible protein–protein interactions’ (EXPLORs), which is able to successfully load cargo proteins into newly generated exosomes using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.

TL;DR: The FasL-Fas system should be considered as a double-edged sword in the CNS: maintaining the immune suppressed status in normal brain and inducing neuronal cell death and inflammation in a variety of neurologic disorders.

TL;DR: The device can be useful for the binary separation of a wide range of biological particles by size and offers potential for a power-free cell sorter to be integrated into disposable lab-on-a-chip devices.

TL;DR: Nox4 plays a central role in LPS-induced proinflammatory responses by endothelial cells in an ROS-dependent manner.