X
X. Ji
Researcher at Chinese Academy of Sciences
Publications - 12
Citations - 1146
X. Ji is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drug delivery & Liposome. The author has an hindex of 5, co-authored 12 publications receiving 1043 citations.
Papers
More filters
Journal ArticleDOI
Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles
TL;DR: Doxorubicin (DOX)-loaded HMSNs (DMSNs) not only demonstrated effective drug loading and a pH-responsive drug release character but also exhibited pore-size-dependent and sustained drug release performance in both in vitro and intracellular drug release experiments.
Journal ArticleDOI
A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance
TL;DR: The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB.
Journal ArticleDOI
Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells.
Yu Chen,Qi Yin,X. Ji,Shengjian Zhang,Hangrong Chen,Yuanyi Zheng,Yang Sun,Haiyun Qu,Zheng Wang,Yaping Li,Xia Wang,Kun Zhang,Linlin Zhang,Jianlin Shi +13 more
TL;DR: The well-defined mesopores and large hollow interiors of HMCNs could encapsulate and deliver anticancer agents intracellularly to circumvent the multidrug resistance (MDR) of cancer cells and restore the anti-proliferative effect of drugs by nanoparticle-mediated endocytosis process, intrACEllular drug release and P-gp inhibition/ATP depletion in cancer cells.
Journal ArticleDOI
Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride‐Silica Chemistry for Efficient Delivery/Co‐Delivery of Hydrophobic Agents
Yu Chen,Yu Gao,Hangrong Chen,Deping Zeng,Yaping Li,Yuanyi Zheng,Faqi Li,X. Ji,Xia Wang,Feng Chen,Qianjun He,Linlin Zhang,Jianlin Shi +12 more
TL;DR: A novel drug‐formulation protocol is developed to solve the delivery problem of hydrophobic drug molecules by using inorganic mesoporous silica nanocapsules (IMNCs) as an alternative to traditional organic emulsion and liposomes while preserving the advantages of inorganic materials.
Journal ArticleDOI
Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance
TL;DR: The cytotoxicity of NLPs against A549/T cells was higher than PTX loaded liposomes without surfactants (LPs), and the best result was achieved after treated with NLPs2.