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Xavier de la Cruz
Researcher at Catalan Institution for Research and Advanced Studies
Publications - 49
Citations - 3047
Xavier de la Cruz is an academic researcher from Catalan Institution for Research and Advanced Studies. The author has contributed to research in topics: Alternative splicing & Regulation of gene expression. The author has an hindex of 20, co-authored 49 publications receiving 2706 citations. Previous affiliations of Xavier de la Cruz include Hebron University & University of Barcelona.
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Journal ArticleDOI
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
Leticia De Mattos-Arruda,Leticia De Mattos-Arruda,Leticia De Mattos-Arruda,Regina Mayor,Charlotte K.Y. Ng,Britta Weigelt,Francisco Martínez-Ricarte,Francisco Martínez-Ricarte,Davis Y. Torrejon,Mafalda Oliveira,Alexandra Arias,C. Raventós,Jiabin Tang,Elena Guerini-Rocco,Elena Martínez-Sáez,Sergio Lois,Oscar Marín,Xavier de la Cruz,Xavier de la Cruz,Salvatore Piscuoglio,Russel Towers,Ana Vivancos,Vicente Peg,Santiago Ramón y Cajal,Santiago Ramón y Cajal,Joan Carles,Jordi Rodon,Maria Gonzalez-Cao,Josep Tabernero,Josep Tabernero,Enriqueta Felip,Enriqueta Felip,Joan Sahuquillo,Joan Sahuquillo,Michael F. Berger,Javier Cortes,Javier Cortes,Jorge S. Reis-Filho,Joan Seoane,Joan Seoane,Joan Seoane +40 more
TL;DR: It is shown that ctDNA derived from central nervous system tumours is more abundantly present in the cerebrospinal fluid (CSF) than in plasma, allowing the identification of actionable brain tumour somatic mutations and facilitating and complement the diagnosis of leptomeningeal carcinomatosis.
Journal ArticleDOI
PMUT: a web-based tool for the annotation of pathological mutations on proteins
Carles Ferrer-Costa,Josep Lluís Gelpí,Leire Zamakola,Ivan Parraga,Xavier de la Cruz,Modesto Orozco +5 more
TL;DR: PMUT allows the fast and accurate prediction of the pathological character of single point amino acidic mutations based on the use of neural networks, which are obtained by three procedures: alanine scanning, massive mutation and genetically accessible mutations.
Journal ArticleDOI
Do protein motifs read the histone code
Xavier de la Cruz,Sergio Lois,Sara Sánchez-Molina,Sara Sánchez-Molina,Marian A. Martínez-Balbás,Marian A. Martínez-Balbás +5 more
TL;DR: Overall, experimental evidence suggests that these domains could be involved in the recruitment of histone‐modifying enzymes to discrete chromosomal locations, and/or in the regulation their enzymatic activity.
Journal ArticleDOI
PupasView: a visual tool for selecting suitable SNPs, with putative pathological effect in genes, for genotyping purposes
Lucia Conde,Juan M. Vaquerizas,Carles Ferrer-Costa,Xavier de la Cruz,Modesto Orozco,Joaquín Dopazo +5 more
TL;DR: PupasView is the first resource that integrates phenotypic effects caused by SNPs at both the translational and the transcriptional level and will be of much help in studies of multifactorial disorders, where the use of functional SNPs will increase the sensitivity of the identification of the genes responsible for the disease.
Journal ArticleDOI
Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties.
TL;DR: The results indicate that a finer understanding can come only from a quantitative knowledge of protein stability and of the protein environment in the cell, and use of evolutionary information from multiple sequence alignments can be used to increase the knowledge of disease-associated mutations.