Xavier Rebordosa

TL;DR: Results indicate that those conditions which prevent the infection by direct adsorption to the cells (presence of a semi-solid medium or presence of neutralizing antibodies in the medium) selectively inhibit the growth of the gE- strain, suggesting that gE plays a central role in the BHV-1 spread by direct cell-to-cell transmission.

TL;DR: An inducible intracellular beta-glucosidase from Streptomyces sp.

TL;DR: An open-reading frame of 1440 nucleotides encoding a polypeptide of 479 amino acids was found by sequencing and the encoded protein appears to be a beta-glucosidase with broad substrate specificity, is active on cellooligomers, and performs transglycosylation reactions.

TL;DR: A region of the unique short sequence from the BHV-1 genome has been sequenced and presents substantial similarity to that of the glycoprotein gE from HSV- 1 and to homologous proteins of related viruses such as pseudorabies virus, equine herpesvirus type 1 and varicella zoster virus.

TL;DR: Recombinant cultures producing the periplasmic, but not the cytoplasmic form show a dramatic arrest of cell growth after induction of gene expression, indicative of toxicity associated to the recombinant protein itself or to its proteolytic processing.