Xi Wang

TL;DR: It is shown that pre-exposure to SARS-CoV-2 could protect mice from severe pneumonia and the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics.

TL;DR: It is shown that TMCO1 is an ER transmembrane protein that actively prevents Ca(2+) stores from overfilling, acting as what the authors term a "Ca(2-) load-activated Ca( 2+) channel" or "CLAC" channel.

TL;DR: Results reveal that TMCO1 is essential for ovarian follicles development and female fertility by maintaining ER Ca2+ homeostasis of GCs, disruption of which causes ER stress-mediated apoptosis and increased cellular ROS level in GCs and thus leads to impaired ovarian follicle development.

TL;DR: It is reported that RBM45 can be recruited to laser microirradiation-induced DNA damage sites in a PAR- and FUS-dependent manner, but in a RNA-independent fashion, and is found to compete with histone deacetylase 1 (HDAC1) for binding to FUS, thereby regulating the recruitment of HDAC1 toDNA damage sites.

TL;DR: The results reveal that protein acetylation might add another layer of complexity to the regulation for spermatogenesis, and further functional studies of these proteins will help to elucidate the mechanisms of abnormal sperMatogenesis.