Xiangju Yin

TL;DR: It is discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy and Mitochondria-targeted antioxidant MitoTEMPO significantly rescued DOX cardiopathy, supporting oxidative damage of mitochondria as a major mechanism in ferroPTosis-induced heart damage.

TL;DR: Findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron‐dependent and iron‐independent mechanisms.

TL;DR: It is concluded that entinostat strongly activated hepcidin in vivo and in vitro and suggested a novel implication of ent inostat in treating iron-overload disorders.

TL;DR: In this paper, a two-sample Mendelian randomization (MR) study was performed to evaluate the causal effect of childhood obesity on long-term cancer risk and found that a 1-SD increase in childhood BMI (kg/m2 ) was significantly associated with a 60% increase in risk of pancreatic cancer (odds ratio [OR]: 1.60; 95% confidence interval [CI]: 112-2.28; P<0.01) and a 47% increase of esophageal cancer (OR: 1.47, 95%

TL;DR: The recent progress of DNA methylation, histone acetylation and miRNA in regulating iron metabolism is summarized and the future research directions are discussed.