Pan Zhang

TL;DR: It is discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy and Mitochondria-targeted antioxidant MitoTEMPO significantly rescued DOX cardiopathy, supporting oxidative damage of mitochondria as a major mechanism in ferroPTosis-induced heart damage.

TL;DR: Findings provide compelling evidence that ferritin plays a major role in protecting against cardiac ferroptosis and subsequent heart failure, thereby providing a possible new therapeutic target for patients at risk of developing cardiomyopathy.

TL;DR: Treating hepatocyte-specific Trf knockout mice with the ferroptosis inhibitor ferrostatin-1 potently rescued liver fibrosis induced by either high dietary iron or carbon tetrachloride (CCl4) injections, and deleting hepatic Slc39a14 expression in Trf-LKO mice significantly reduced hepatic iron accumulation, indicate that hepatic transferrin plays a protective role in maintaining liver function.

TL;DR: Physical activity may be an important protective factor for preventing the development of Parkinson disease among at-risk men and large prospective studies should be performed to examine this association and to investigate the factors that underlie the observed sex difference.

TL;DR: Findings provide direct evidence that Tfr1 is essential for hematopoiesis through binding diferric transferrin to supply iron to cells.