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Xiangwen Dong
Researcher at University of Iowa
Publications - 4
Citations - 360
Xiangwen Dong is an academic researcher from University of Iowa. The author has contributed to research in topics: Palmitoylation & Endoplasmic reticulum. The author has an hindex of 3, co-authored 3 publications receiving 352 citations.
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Journal ArticleDOI
Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.
TL;DR: Subcellular fractionation and immunolocalization experiments reveal that Erf2 tagged with a triply iterated hemagglutinin epitope is an integral membrane protein that colocalizes with the yeast endoplasmic reticulum marker Kar2, suggesting that ErF2 plays a role in Ras localization in all eucaryotes.
Journal ArticleDOI
Erf4p and Erf2p Form an Endoplasmic Reticulum-associated Complex Involved in the Plasma Membrane Localization of Yeast Ras Proteins
TL;DR: It is shown that Erf4p is localized on the endoplasmic reticulum as a peripheral membrane protein in a complex with Erf2p, an integral membrane protein that was identified from the same genetic screen.
Journal ArticleDOI
Palmitoylation and Plasma Membrane Localization of Ras2p by a Nonclassical Trafficking Pathway in Saccharomyces cerevisiae
Xiangwen Dong,David A. Mitchell,Sandra Lobo,Lihong Zhao,Douglas J. Bartels,Robert J. Deschenes +5 more
TL;DR: This report shows that plasma membrane localization of Ras2p in Saccharomyces cerevisiae does not require the classical secretory pathway or a functional Golgi apparatus, and provides evidence for the existence of a palmitoylation-dependent, nonclassical endomembrane trafficking system for the plasma membrane localized of Ras proteins.
Journal ArticleDOI
First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children with CNGB3-associated Achromatopsia.
Michel Michaelides,Nashila Hirji,Sui Wong,Cagri G. Besirli,Serena Zaman,Neruban Kumaran,Anastasios Georgiadis,Alexander J. Smith,Caterina Ripamonti,Irene Gottlob,A. Robson,Alberta A H J Thiadens,Robert H. Henderson,Penny R. Fleck,Eddy Anglade,Xiangwen Dong,George Capuano,Wentao Lu,Pamela Berry,Thomas Kane,Stuart Naylor,Michalis Georgiou,Angelos Kalitzeos,Robin R. Ali,Alexandra Lindsay Forbes,James W B Bainbridge +25 more
TL;DR: In this paper , the authors evaluated the safety and efficacy of AAV8-hCARp.hCNGB3 in participants with CNGB3-associated achromatopsia (ACHM).