J
James W B Bainbridge
Researcher at UCL Institute of Ophthalmology
Publications - 197
Citations - 11379
James W B Bainbridge is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 51, co-authored 191 publications receiving 9932 citations. Previous affiliations of James W B Bainbridge include University of London & University College London.
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Journal ArticleDOI
Effect of gene therapy on visual function in Leber's congenital amaurosis.
James W B Bainbridge,Alexander J. Smith,Susie S Barker,Scott J Robbie,Robert H. Henderson,Kamaljit S. Balaggan,Ananth C. Viswanathan,Graham E. Holder,Andrew Stockman,Nick Tyler,Simon M. Petersen-Jones,Shomi S. Bhattacharya,Adrian J. Thrasher,Fred W. Fitzke,Barrie J Carter,Gary S. Rubin,Anthony T. Moore,Robin R. Ali +17 more
TL;DR: Three young adult patients with early-onset, severe retinal dystrophy were administered subretinal injections of recombinant adeno-associated virus vector 2/2 expressing RPE65 complementary DNA (cDNA) under the control of a human R PE65 promoter.
Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal ArticleDOI
Restoration of vision after transplantation of photoreceptors
Rachael A. Pearson,Amanda C. Barber,Matteo Rizzi,Claire Hippert,Tian Xue,Emma L. West,Yanai Duran,Alexander J. Smith,Jen-Zen Chuang,Selina A. Azam,Ulrich F O Luhmann,Andrea Benucci,Ching-Hwa Sung,James W B Bainbridge,Matteo Carandini,King Wai Yau,Jane C. Sowden,Robin R. Ali,Robin R. Ali +18 more
TL;DR: Evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1−/− mice is provided and it is demonstrated that visual signals generated by transplanted rods are projected to higher visual areas, including V1.
Journal ArticleDOI
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
Anai Gonzalez-Cordero,Emma L. West,Rachael A. Pearson,Yanai Duran,Livia S. Carvalho,Colin J Chu,Arifa Naeem,Samuel J.I. Blackford,Anastasios Georgiadis,Jorn Lakowski,Mike Hubank,Alexander J. Smith,James W B Bainbridge,Jane C. Sowden,Robin R. Ali,Robin R. Ali +15 more
TL;DR: This study shows conclusively that ESCs can provide a source of photoreceptors for retinal cell transplantation and adapted a recently reported three-dimensional differentiation protocol that generates neuroretina from mouse ESCs to isolate photoreceptor precursors fit for transplantation.
Journal ArticleDOI
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
Xiaomeng Wang,Sabu Abraham,Jenny A. G. McKenzie,Natasha Jeffs,Matthew Swire,Vineeta Tripathi,Ulrich F O Luhmann,Clemens Lange,Clemens Lange,Zhenhua Zhai,Helen M. Arthur,James W B Bainbridge,James W B Bainbridge,Stephen E. Moss,John Greenwood +14 more
TL;DR: A new regulator of angiogenesis is revealed that mediates its effect by modulating TGF-β signalling, and is revealed to be leucine-rich alpha-2-glycoprotein 1 (Lrg1), of previously unknown function.