Anastasios Georgiadis

TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.

TL;DR: This study shows conclusively that ESCs can provide a source of photoreceptors for retinal cell transplantation and adapted a recently reported three-dimensional differentiation protocol that generates neuroretina from mouse ESCs to isolate photoreceptor precursors fit for transplantation.

TL;DR: It is shown that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors, raising the possibility of materialtransfer as a strategy for the treatment of retinal disorders.

TL;DR: Results indicate that ZONAB regulates the transcription of genes that are important for G1/S-phase progression and links tight junctions to the transcriptional control of key cell cycle regulators and epithelial cell differentiation.

TL;DR: In this paper, an HIV-based lentiviral vector encoding the human factor IX protein was introduced into the fetal circulation of immunocompetent hemophiliac and normal outbred mice.