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Xiangyan Qiu
Researcher at University of Texas Southwestern Medical Center
Publications - 5
Citations - 646
Xiangyan Qiu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immunotherapy & T cell. The author has an hindex of 4, co-authored 4 publications receiving 339 citations.
Papers
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Journal ArticleDOI
PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression
Haidong Tang,Yong Liang,Robert A. Anders,Janis M. Taube,Xiangyan Qiu,Aditi Mulgaonkar,Xin Liu,Susan M. Harrington,Jingya Guo,Yangchun Xin,Yahong Xiong,Kien Nham,William Silvers,Guiyang Hao,Xiankai Sun,Mingyi Chen,Raquibul Hannan,Jian Qiao,Haidong Dong,Hua Peng,Yang Xin Fu +20 more
TL;DR: It is demonstrated that PD-L1 expressed in APCs, rather than on tumor cells, plays an essential role in checkpoint blockade therapy, providing an insight into the mechanisms of this therapy.
Journal ArticleDOI
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
Qi Peng,Xiangyan Qiu,Zihan Zhang,Silin Zhang,Yuan-Yuan Zhang,Yong Liang,Jingya Guo,Hua Peng,Mingyi Chen,Yang Xin Fu,Haidong Tang +10 more
TL;DR: A critical and dynamic role of PD-L1 on dendritic cells is identified, which needs to be harnessed for better invigoration of antitumor immune responses.
Journal ArticleDOI
Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
Yong Liang,Haidong Tang,Haidong Tang,Jingya Guo,Xiangyan Qiu,Zecheng Yang,Zhenhua Ren,Zhichen Sun,Yingjie Bian,Lily Xu,Hairong Xu,Jiao Shen,Yanfei Han,Haidong Dong,Hua Peng,Yang Xin Fu +15 more
TL;DR: PD-L 1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.
Book ChapterDOI
Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy
TL;DR: The general approach to establish transplantable mouse tumor models for the study of immunotherapy is described and the strategies for therapy through systemic or local treatment targeting TLS are introduced.
Journal ArticleDOI
Vimentin as a potential target for diverse nervous system diseases
TL;DR: The potential therapeutic methods involving vimentin manipulation in improving axonal regeneration, alleviating infection, inhibiting brain tumor progression, and enhancing nerve myelination are discussed.