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Xianning Lai
Researcher at National University of Singapore
Publications - 12
Citations - 452
Xianning Lai is an academic researcher from National University of Singapore. The author has contributed to research in topics: DNA damage & Ubiquitin-conjugating enzyme. The author has an hindex of 7, co-authored 12 publications receiving 339 citations. Previous affiliations of Xianning Lai include St. Vincent's Institute of Medical Research & University of Melbourne.
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Journal ArticleDOI
Triple negative breast cancer in Asia: An insider's view.
Chao Wang,Shreya Kar,Xianning Lai,Wanpei Cai,Frank Arfuso,Gautam Sethi,Peter E. Lobie,Boon Cher Goh,Lina H. K. Lim,Mikael Hartman,Ching Wan Chan,Soo Chin Lee,Sing H. Tan,Alan Prem Kumar +13 more
TL;DR: This review encapsulates the studies conducted on TNBC patients in Asian population and elucidates the similarities and differences between these two regions to facilitate the development of better treatment strategies to combat TNBC.
Journal ArticleDOI
MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
Xianning Lai,Ronan Broderick,Valérie Bergoglio,Jutta Zimmer,Sophie Badie,Wojciech Niedzwiedz,Jean-Sébastien Hoffmann,Madalena Tarsounas +7 more
TL;DR: This article showed that MUS81 nucleolytic activity is required to activate compensatory DNA synthesis during mitosis and to resolve mitotic interlinks, thus facilitating chromosome segregation in BRCA2-deficient cells.
Journal ArticleDOI
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
Eliana M.C. Tacconi,Xianning Lai,Cecilia Folio,Manuela Porru,Gijs Zonderland,Sophie Badie,Johanna Michl,Irene Sechi,Mélanie Rogier,Verónica Matía García,Ankita Sati Batra,Oscar M. Rueda,Peter Bouwman,Jos Jonkers,Anderson J. Ryan,Bernardo Reina-San-Martin,Joannie Hui,Nelson L.S. Tang,Alejandra Bruna,Annamaria Biroccio,Madalena Tarsounas +20 more
TL;DR: It is found that disulfiram (Antabuse), an ALDH2 inhibitor in widespread clinical use for the treatment of alcoholism, selectively eliminates BRCA1/2‐deficient cells and tumors.
Journal ArticleDOI
Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34
Martin C. Sadowski,Randy Suryadinata,Xianning Lai,Jörg Heierhorst,Jörg Heierhorst,Boris Sarcevic +5 more
TL;DR: In this paper, the authors studied the polyubiquitination of Sic1 by the E2 protein Cdc34 and the RING E3 Skp1/Cul1/F-box (SCF) protein and showed that the proximal amino acids surrounding the lysine residues in Sic1 and Ub are critical for ubiquitination.
Journal ArticleDOI
Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
Xianning Lai,Ronan Broderick,Valérie Bergoglio,Jutta Zimmer,Sophie Badie,Wojciech Niedzwiedz,Jean-Sébastien Hoffmann,Madalena Tarsounas +7 more
TL;DR: This corrects the article DOI: 10.1038/ncomms15983 to Ncomms 15983 instead of NCOMMS 15984, which is closer to the truth.