N
Nelson L.S. Tang
Researcher at The Chinese University of Hong Kong
Publications - 300
Citations - 15627
Nelson L.S. Tang is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 54, co-authored 296 publications receiving 14314 citations. Previous affiliations of Nelson L.S. Tang include Kwong Wah Hospital & Peking Union Medical College Hospital.
Papers
More filters
Journal ArticleDOI
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies
Antonis C. Antoniou,Paul D.P. Pharoah,Steven A. Narod,Harvey A. Risch,Jorunn E. Eyfjord,John L. Hopper,Niklas Loman,Håkan Olsson,Oskar T. Johannsson,Åke Borg,Barbara Pasini,Paolo Radice,Siranoush Manoukian,Diana Eccles,Nelson L.S. Tang,E. Olah,Hoda Anton-Culver,Ellen Warner,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Hrafn Tulinius,Steinunn Thorlacius,Hannaleena Eerola,Heli Nevanlinna,Kirsi Syrjäkoski,Olli Kallioniemi,Deborah J. Thompson,Christopher H. Evans,Julian Peto,Julian Peto,Fiona Lalloo,D G R Evans,Douglas F. Easton +33 more
TL;DR: Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found.
Journal ArticleDOI
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.
Antonis C. Antoniou,Alex P Cunningham,Julian Peto,D G R Evans,Fiona Lalloo,Steven A. Narod,Harvey A. Risch,Jorunn E. Eyfjord,John L. Hopper,Melissa C. Southey,Håkan Olsson,Oskar T. Johannsson,Åke Borg,Barbara Pasini,Paolo Radice,Siranoush Manoukian,Diana Eccles,Nelson L.S. Tang,E. Olah,Hoda Anton-Culver,Ellen Warner,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Laufey Tryggvadottir,Kirsi Syrjäkoski,O. P. Kallioniemi,H Eerola,Heli Nevanlinna,Paul D.P. Pharoah,Douglas F. Easton +30 more
TL;DR: BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program.
Journal ArticleDOI
BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
TL;DR: BOOST has identified some disease-associated interactions between genes in the major histocompatibility complex region in the type 1 diabetes data set and can serve as a computationally and statistically useful tool in the coming era of large-scale interaction mapping in genome-wide case-control studies.
Journal ArticleDOI
Pathology of fatal human infection associated with avian influenza A H5N1 virus.
Ka Fai To,Paul K.S. Chan,Kui-Fat Chan,Wai-Ki Lee,Woon-Yee Lam,Kit-Fai Wong,Nelson L.S. Tang,Dominic N.C. Tsang,Rita Y T Sung,T. A. Buckley,John S. Tam,Augustine F. B. Cheng +11 more
TL;DR: It is postulated that in fatal human infections with this avian subtype, initial virus replication in the respiratory tract triggers hypercytokinemia complicated by the reactive hemophagocytic syndrome.
Posted Content
BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies
TL;DR: In this paper, a simple but powerful method, named "BOolean Operation based Screening and Testing" (BOOST), is introduced to discover unknown gene-gene interactions that underlie complex diseases.