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Xiao Ou Mao
Researcher at Buck Institute for Research on Aging
Publications - 70
Citations - 13692
Xiao Ou Mao is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Neurogenesis & Subventricular zone. The author has an hindex of 50, co-authored 70 publications receiving 13133 citations.
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Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
TL;DR: Using BrdU labeling as an index of cell proliferation, it is found that the in vitro neuroproliferative effect of VEGF was associated with up‐regulation of E2F family transcription factors, Cyclin D1, cyclin E, and cdc25, consistent with regulation of the G1/S phase transition of the cell cycle.
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Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat.
Kunlin Jin,Yunjuan Sun,Lin Xie,Xiao Ou Mao,Joycelyn Childs,Alyson Peel,Anna Logvinova,Surita Banwait,David A. Greenberg +8 more
TL;DR: Transplantation of neural precursors by a variety of routes can deliver cells with the potential to replace injured neurons to ischemic brain regions and enhance their migration when delivered by any of these routes.
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MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad.
TL;DR: Findings suggest that a cell‐survival program involving phospho‐activation of MEK1/2 and ERK1 /2 and inactivation of Bad is mobilized in hypoxic neurons, and may help to regulate neuronal fate following hypoxic‐ischemic injury.
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Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice
TL;DR: It is reported that S OD1G93A/VEGF+/+ double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1G 93A single transgenics.
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Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor.
TL;DR: It is reported that in mouse cortical neuron cultures subjected to hypoxia, the neuroprotective effect of VEGF involves suppression of cell-death pathways mediated by caspase-3, and could therefore act as an endogenous neuroProtective factor in cerebral ischemia.