https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review

Fungal natural products in research and development

Toxicity of raw and processed roots of Polygonum multiflorum

Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor

Five series of 37 new acylate and epoxide derivatives (3–39) of Euphorbia factor L3, a lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure–activity relationship study of these compounds. The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.

Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.

Four new alkaloids, brevianamides O - R (1-4, resp.), were isolated from the AcOEt extract of the solid-state fermented rice culture of the fungus Aspergillus versicolor. Their structures were elucidated on the basis of spectroscopic analyses.

Four New Alkaloids, Brevianamides O-R, from the Fungus Aspergillus versicolor

Figure 1. Phenolic glycosides: 3-hydroxy-4-O-b-D-(6-Oacetylglucopyranosyl)benzyl vanilloate (litseaefoloside A (1), Mr 494.1424); 3-hydroxy-4-O-b-Dglucopyranosylbenzyl vanilloate (vanilloylcalleryanin (2), Mr 452.1319); 4-O-b-Dglucopyranosylbenzyl vanilloate (3, Mr 436.1369); 3-hydroxy4-O-b-D-(6-O-caffeoylglucopyranosyl)benzyl vanilloate (litseaefoloside C (4), Mr 614.1636); 3-hydroxy-4-O-b-D-(6-Ovanilloylglucopyranosyl)benzyl vanilloate (litseaefoloside D (5), Mr 602.1636); 4-O-b-D-(6-O-vanilloylglucopyranosyl)vanillic acid (6, Mr 480.1268). Dear Editor,

Xiao-Zhen Chen

Papers

Toxicity of raw and processed roots of Polygonum multiflorum

Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor

Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.

Four New Alkaloids, Brevianamides O-R, from the Fungus Aspergillus versicolor

Analysis of phenolic glycosides from Ilex litseaefolia using electrospray ionization quadrupole time-of-flight mass spectrometry.