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Xiaohong Liang
Researcher at Shandong University
Publications - 101
Citations - 2919
Xiaohong Liang is an academic researcher from Shandong University. The author has contributed to research in topics: Hepatitis B virus & T cell. The author has an hindex of 25, co-authored 81 publications receiving 2069 citations. Previous affiliations of Xiaohong Liang include University of Pennsylvania.
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Journal ArticleDOI
Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
Yuan Liu,Yufeng Cheng,Yeyang Xu,Zhen Wang,Xianhong Du,Chunyang Li,Jiali Peng,Lifen Gao,Xiaohong Liang,Chunhong Ma +9 more
TL;DR: It is shown that programmed cell death protein 1 (PD-1), a well-known immune checkpoint of T cells, is highly expressed on peripheral and tumor-infiltrating NK cells from patients with digestive cancers, and PD-1 blockade might be an efficient strategy in NK cell-based tumor immunotherapy.
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Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages
Wenjiang Yan,Xiao Liu,Hongxin Ma,Hualin Zhang,Xiaojia Song,Lifen Gao,Xiaohong Liang,Chunhong Ma +7 more
TL;DR: Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC and significantly inhibited the alternative activation of macrophages and suppressed HCC cell growth both in vitro and in vivo.
Journal ArticleDOI
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B
Ying Ju,Nan Hou,Jing Meng,Xiaoyan Wang,Xiaoning Zhang,Di Zhao,Ying Liu,Faliang Zhu,Lining Zhang,Wensheng Sun,Xiaohong Liang,Lifen Gao,Chunhong Ma,Chunhong Ma +13 more
TL;DR: HBV infection can up-regulate Tim-3 expression in NK cells, which may in turn suppress NK-cell functions in chronic Hepatitis B patients.
Journal ArticleDOI
Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax
Xiaohong Liang,Yugang Liu,Qiu Zhang,Lifen Gao,Lihui Han,Chunhong Ma,Lining Zhang,Youhai H. Chen,Wensheng Sun +8 more
TL;DR: It is established that HBV sensitizes hepatocytes to TRAIL-induced apoptosis through Bax and that Bax-specific small interference RNA can be used to inhibit HBV-induced hepatic cell death.
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Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice.
Wenjin Xi,Yejia Hu,Yejia Hu,Yugang Liu,Jiao Zhang,Lei Wang,Yunwei Lou,Zhonghua Qu,Jian Cui,Guizhong Zhang,Xiaohong Liang,Chunhong Ma,Chengjiang Gao,Youhai H. Chen,Suxia Liu +14 more
TL;DR: It is reported here that the tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2 or TNFAIP8L2), a newly identified regulator of immune receptor signaling, plays an important role in controlling HBV-induced hepatitis.